ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dihydropyrimidinase-related protein 4

Intramolecular
Cysteine 90 and cysteine 132
Cysteine 174 and cysteine 176
Cysteine 132 and cysteine 133
Cysteine 319 and cysteine 369
A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 4 between cysteines 90 and 132.

Details

Redox score ?
66
PDB code
5nks
Structure name
human dihydropyrimidinase-related protein 4 (dpysl4, crmp3, ulip-4)
Structure deposition date
2017-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
42
Peptide accession
O14531
Residue number A
90
Residue number B
132
Peptide name
Dihydropyrimidinase-related protein 4

Ligandability

Cysteine 90 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 4 between cysteines 174 and 176. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5nks
Structure name
human dihydropyrimidinase-related protein 4 (dpysl4, crmp3, ulip-4)
Structure deposition date
2017-03-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
74
Peptide accession
O14531
Residue number A
174
Residue number B
176
Peptide name
Dihydropyrimidinase-related protein 4

Ligandability

Cysteine 174 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 4 between cysteines 132 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5nks
Structure name
human dihydropyrimidinase-related protein 4 (dpysl4, crmp3, ulip-4)
Structure deposition date
2017-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
11
% buried
78
Peptide accession
O14531
Residue number A
132
Residue number B
133
Peptide name
Dihydropyrimidinase-related protein 4

Ligandability

Cysteine 132 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dihydropyrimidinase-related protein 4 between cysteines 319 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5nks
Structure name
human dihydropyrimidinase-related protein 4 (dpysl4, crmp3, ulip-4)
Structure deposition date
2017-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
48
Peptide accession
O14531
Residue number A
319
Residue number B
369
Peptide name
Dihydropyrimidinase-related protein 4

Ligandability

Cysteine 319 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 369 of Dihydropyrimidinase-related protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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