ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Suppressor of cytokine signaling 3

Intermolecular
Cysteine 193 and cysteine 112 of Elongin-C
Intramolecular
Cysteine 97 and cysteine 119
A redox-regulated disulphide may form between cysteine 193 of Suppressor of cytokine signaling 3 and cysteine 112 of Elongin-C (8 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2jz3
Structure name
socs box elonginbc ternary complex
Structure deposition date
2007-12-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
24
Peptide A name
Suppressor of cytokine signaling 3
Peptide B name
Elongin-C
Peptide A accession
O35718
Peptide B accession
P83940
Peptide A residue number
193
Peptide B residue number
112

Ligandability

Cysteine 193 of Suppressor of cytokine signaling 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Elongin-C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Suppressor of cytokine signaling 3 between cysteines 97 and 119 (68 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2bbu
Structure name
solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor
Structure deposition date
2005-10-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
28
Peptide accession
O35718
Residue number A
97
Residue number B
119
Peptide name
Suppressor of cytokine signaling 3

Ligandability

Cysteine 97 of Suppressor of cytokine signaling 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Suppressor of cytokine signaling 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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