ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Intramolecular
Cysteine 224 and cysteine 228
Cysteine 126 and cysteine 201
A redox-regulated disulphide may form within Glyceraldehyde-3-phosphate dehydrogenase, testis-specific between cysteines 224 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3pfw
Structure name
crystal structure of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (gapds) complex with nad, a binary form
Structure deposition date
2010-10-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
10
% buried
100
Peptide accession
O14556
Residue number A
224
Residue number B
228
Peptide name
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Ligandability

Cysteine 224 of Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glyceraldehyde-3-phosphate dehydrogenase, testis-specific between cysteines 126 and 201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5c7i
Structure name
mouse sperm glyceraldehyde-3-phosphate dehydrogenase: apo enzyme
Structure deposition date
2015-06-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
98
Peptide accession
Q64467
Residue number A
126
Residue number B
201
Peptide name
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Ligandability

Cysteine 126 of Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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