Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Intermolecular
Cysteine 89 and cysteine 89
Intramolecular
Cysteine 159 and cysteine 180
Cysteine 192 and cysteine 198
Cysteine 103 and cysteine 159
2q5e F 89 H 89
A redox-regulated disulphide may form between two units of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 at cysteines 89 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2q5e
Structure name
crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Peptide B name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Peptide A accession
O14595
Peptide B accession
O14595
Peptide A residue number
89
Peptide B residue number
89
Ligandability
2q5e F 159 F 180
A redox-regulated disulphide may form within Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 between cysteines 159 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2q5e
Structure name
crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2
Structure deposition date
2007-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
58
Peptide accession
O14595
Residue number A
159
Residue number B
180
Peptide name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Ligandability
Cysteine 159 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Cysteine 180 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
2q5e E 192 E 198
A redox-regulated disulphide may form within Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 between cysteines 192 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
2q5e
Structure name
crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2
Structure deposition date
2007-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
96
Peptide accession
O14595
Residue number A
192
Residue number B
198
Peptide name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Ligandability
Cysteine 192 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Cysteine 198 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
2q5e G 103 G 159
A redox-regulated disulphide may form within Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 between cysteines 103 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
2q5e
Structure name
crystal structure of human carboxy-terminal domain rna polymerase ii polypeptide a small phosphatase 2
Structure deposition date
2007-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
98
Peptide accession
O14595
Residue number A
103
Residue number B
159
Peptide name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Ligandability
Cysteine 103 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Cysteine 159 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
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