ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-X-C motif chemokine 11

Intramolecular
Cysteine 30 and cysteine 57
Cysteine 32 and cysteine 74
Cysteine 30 and cysteine 32
Cysteine 32 and cysteine 57
Cysteine 30 and cysteine 74
Cysteine 57 and cysteine 74
A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 30 and 57 (9 and 36 respectively in this structure).

Details

Redox score ?
88
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
30
Residue number B
57
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 30 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 32 and 74 (11 and 53 respectively in this structure).

Details

Redox score ?
83
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
32
Residue number B
74
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 32 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 30 and 32 (9 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
30
Residue number B
32
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 30 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 32 and 57 (11 and 36 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
32
Residue number B
57
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 32 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 30 and 74 (9 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
30
Residue number B
74
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 30 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-X-C motif chemokine 11 between cysteines 57 and 74 (36 and 53 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1rjt
Structure name
nmr structure of cxc chemokine cxcl11/itac
Structure deposition date
2003-11-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14625
Residue number A
57
Residue number B
74
Peptide name
C-X-C motif chemokine 11

Ligandability

Cysteine 57 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of C-X-C motif chemokine 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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