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Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Intramolecular
Cysteine 577 and cysteine 664
Cysteine 577 and cysteine 664
Cysteine 380 and cysteine 478
Cysteine 575 and cysteine 679
Cysteine 75 and cysteine 81
Cysteine 787 and cysteine 797
Cysteine 119 and cysteine 125
Cysteine 144 and cysteine 190
Cysteine 429 and cysteine 818
Cysteine 153 and cysteine 365
More...
Cysteine 103 and cysteine 133
Cysteine 69 and cysteine 82
Cysteine 54 and cysteine 71
Cysteine 58 and cysteine 89
Cysteine 98 and cysteine 115
Cysteine 562 and cysteine 623
Cysteine 113 and cysteine 126
Cysteine 98 and cysteine 133
Cysteine 71 and cysteine 82
Cysteine 54 and cysteine 82
Cysteine 54 and cysteine 89
Cysteine 98 and cysteine 126
Cysteine 115 and cysteine 133
Cysteine 115 and cysteine 126
Cysteine 98 and cysteine 103
Cysteine 71 and cysteine 89
Cysteine 55 and cysteine 59
Cysteine 98 and cysteine 119
Cysteine 54 and cysteine 75
Cysteine 54 and cysteine 69
Cysteine 70 and cysteine 72
Cysteine 98 and cysteine 113
Cysteine 113 and cysteine 115
Cysteine 103 and cysteine 115
Cysteine 58 and cysteine 71
Cysteine 115 and cysteine 119
Cysteine 119 and cysteine 133
Cysteine 54 and cysteine 81
Cysteine 71 and cysteine 75
Cysteine 98 and cysteine 125
A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 577 and 664.

Details

Redox score ?
88
PDB code
6f33
Structure name
crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase- 3 (npp3) in complex with ampnpp
Structure deposition date
2017-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97675
Residue number A
577
Residue number B
664
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 577 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 664 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 577 and 664.

Details

Redox score ?
87
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
577
Residue number B
664
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 577 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 664 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 380 and 478.

Details

Redox score ?
87
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
380
Residue number B
478
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 380 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 575 and 679.

Details

Redox score ?
87
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
575
Residue number B
679
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 575 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 75 and 81.

Details

Redox score ?
86
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
75
Residue number B
81
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 75 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 787 and 797.

Details

Redox score ?
86
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
787
Residue number B
797
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 787 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 797 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 119 and 125.

Details

Redox score ?
86
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
119
Residue number B
125
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 119 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 144 and 190.

Details

Redox score ?
85
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
144
Residue number B
190
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 144 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 429 and 818.

Details

Redox score ?
84
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
429
Residue number B
818
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 429 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 818 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 153 and 365.

Details

Redox score ?
84
PDB code
6f2y
Structure name
crystal structure of ectonucleotide phosphodiesterase/pyrophosphatase- 3 (npp3) in complex with ap4a
Structure deposition date
2017-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97675
Residue number A
153
Residue number B
365
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 153 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 103 and 133.

Details

Redox score ?
84
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
103
Residue number B
133
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 103 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 69 and 82.

Details

Redox score ?
83
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
69
Residue number B
82
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 69 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 71.

Details

Redox score ?
83
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
71
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 58 and 89.

Details

Redox score ?
82
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
58
Residue number B
89
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 58 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 115.

Details

Redox score ?
82
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
115
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 562 and 623.

Details

Redox score ?
82
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
562
Residue number B
623
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 562 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 623 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 113 and 126.

Details

Redox score ?
78
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
113
Residue number B
126
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 113 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 133.

Details

Redox score ?
74
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
133
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 71 and 82.

Details

Redox score ?
73
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
71
Residue number B
82
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 71 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 82.

Details

Redox score ?
73
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
82
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 89.

Details

Redox score ?
69
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
89
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 126.

Details

Redox score ?
68
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
126
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 115 and 133.

Details

Redox score ?
67
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
115
Residue number B
133
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 115 and 126.

Details

Redox score ?
67
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
115
Residue number B
126
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 103.

Details

Redox score ?
65
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
103
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 71 and 89.

Details

Redox score ?
63
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
71
Residue number B
89
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 71 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 55 and 59.

Details

Redox score ?
62
PDB code
6g4g
Structure name
full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (npp3) including the smb domains but with a partially disordered active site structure
Structure deposition date
2018-03-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97675
Residue number A
55
Residue number B
59
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 55 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 59 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 119.

Details

Redox score ?
62
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
119
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 75.

Details

Redox score ?
62
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
75
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 69.

Details

Redox score ?
61
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
69
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 70 and 72.

Details

Redox score ?
61
PDB code
6g4g
Structure name
full length ectodomain of ectonucleotide phosphodiesterase/pyrophosphatase-3 (npp3) including the smb domains but with a partially disordered active site structure
Structure deposition date
2018-03-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P97675
Residue number A
70
Residue number B
72
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 70 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
113
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 113 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
113
Residue number B
115
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 113 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 103 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
103
Residue number B
115
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 103 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 58 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
58
Residue number B
71
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 58 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 115 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
115
Residue number B
119
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 115 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 119 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
119
Residue number B
133
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 119 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 54 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6c02
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c), inactive (t205a), n594s, with alpha,beta-methylene-atp (ampcpp)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
54
Residue number B
81
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 54 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 71 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
71
Residue number B
75
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 71 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 between cysteines 98 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6c01
Structure name
human ectonucleotide pyrophosphatase / phosphodiesterase 3 (enpp3, npp3, cd203c)
Structure deposition date
2017-12-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14638
Residue number A
98
Residue number B
125
Peptide name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Ligandability

Cysteine 98 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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