ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Torsin-1A

Intramolecular
Cysteine 280 and cysteine 319
Cysteine 320 and cysteine 50
A redox-regulated disulphide may form within Torsin-1A between cysteines 280 and 319.

Details

Redox score ?
74
PDB code
5j1s
Structure name
torsina-lull1 complex, h
Structure deposition date
2016-03-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
100
Peptide accession
O14656
Residue number A
280
Residue number B
319
Peptide name
Torsin-1A

Ligandability

Cysteine 280 of Torsin-1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Torsin-1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Torsin-1A between cysteines 320 and 50 (320 and 349 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6fv0
Structure name
crystal structure of the tpr domain of klc1 in complex with the c- terminal peptide of torsina
Structure deposition date
2018-02-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
80
Peptide accession
Q9ER39
Residue number A
320
Residue number B
50
Peptide name
Torsin-1A

Ligandability

Cysteine 320 of Torsin-1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 of Torsin-1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 in protein A could not be asigned to a Uniprot residue.
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