Disintegrin and metalloproteinase domain-containing protein 10
Intramolecular
Cysteine 555 and cysteine 567
Cysteine 530 and cysteine 562
Cysteine 524 and cysteine 543
Cysteine 483 and cysteine 515
Cysteine 632 and cysteine 645 L
Cysteine 510 and cysteine 536
Cysteine 460 and cysteine 495
Cysteine 580 and cysteine 607
Cysteine 572 and cysteine 598
Cysteine 473 and cysteine 479
More...Cysteine 582 and cysteine 597
Cysteine 503 and cysteine 511
Cysteine 471 and cysteine 484
Cysteine 344 and cysteine 451
Cysteine 594 and cysteine 639
Cysteine 524 and cysteine 536
Cysteine 399 and cysteine 435 L
Cysteine 222 and cysteine 313
Cysteine 510 and cysteine 524
Cysteine 530 and cysteine 555
Cysteine 510 and cysteine 543
Cysteine 632 and cysteine 639 L
Cysteine 555 and cysteine 562
Cysteine 582 and cysteine 607
Cysteine 536 and cysteine 543
Cysteine 530 and cysteine 567
Cysteine 597 and cysteine 607
Cysteine 594 and cysteine 632 L
Cysteine 639 and cysteine 645
Cysteine 313 and cysteine 451
Cysteine 473 and cysteine 484
Cysteine 562 and cysteine 567
Cysteine 483 and cysteine 511
Cysteine 479 and cysteine 484
Cysteine 484 and cysteine 495
Cysteine 594 and cysteine 645
Cysteine 511 and cysteine 515
Cysteine 503 and cysteine 515
Cysteine 483 and cysteine 503
Cysteine 484 and cysteine 503
5l0q A 555 A 567
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 555 and 567.
Details
Redox score ?
86
PDB code
5l0q
Structure name
crystal structure of the complex between adam10 d+c domain and a conformation specific mab 8c7
Structure deposition date
2016-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
555
Residue number B
567
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 555 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 567 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 530 A 562
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 530 and 562.
Details
Redox score ?
86
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
530
Residue number B
562
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 530 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 562 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 524 D 543
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 524 and 543.
Details
Redox score ?
86
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
524
Residue number B
543
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 524 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 543 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 483 A 515
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 483 and 515.
Details
Redox score ?
86
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
483
Residue number B
515
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 483 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 515 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 632 C 645
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 632 and 645.
Details
Redox score ?
85
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
632
Residue number B
645
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 632 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 645 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 510 C 536
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 510 and 536.
Details
Redox score ?
85
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
510
Residue number B
536
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 510 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 536 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 B 460 B 495
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 460 and 495.
Details
Redox score ?
85
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
460
Residue number B
495
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 460 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 495 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 580 D 607
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 580 and 607.
Details
Redox score ?
83
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
580
Residue number B
607
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 580 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 607 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 B 572 B 598
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 572 and 598.
Details
Redox score ?
83
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
572
Residue number B
598
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 572 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 598 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 473 D 479
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 473 and 479.
Details
Redox score ?
82
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
473
Residue number B
479
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 473 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 479 of Disintegrin and metalloproteinase domain-containing protein 10
5l0q D 582 D 597
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 582 and 597.
Details
Redox score ?
82
PDB code
5l0q
Structure name
crystal structure of the complex between adam10 d+c domain and a conformation specific mab 8c7
Structure deposition date
2016-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
582
Residue number B
597
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 582 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 597 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 503 C 511
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 503 and 511.
Details
Redox score ?
82
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
503
Residue number B
511
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 503 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 511 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 471 C 484
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 471 and 484.
Details
Redox score ?
81
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
471
Residue number B
484
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 471 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 484 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 344 A 451
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 344 and 451.
Details
Redox score ?
81
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
344
Residue number B
451
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 344 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 451 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 594 D 639
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 594 and 639.
Details
Redox score ?
80
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
594
Residue number B
639
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 594 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 639 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 B 524 B 536
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 524 and 536.
Details
Redox score ?
79
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
524
Residue number B
536
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 524 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 536 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 399 C 435
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 399 and 435.
Details
Redox score ?
79
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
399
Residue number B
435
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 399 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 435 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 222 C 313
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 222 and 313.
Details
Redox score ?
78
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
222
Residue number B
313
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 222 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 313 of Disintegrin and metalloproteinase domain-containing protein 10
6bdz A 510 A 524
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 510 and 524.
Details
Redox score ?
78
PDB code
6bdz
Structure name
adam10 extracellular domain bound by the 11g2 fab
Structure deposition date
2017-10-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
510
Residue number B
524
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 510 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 524 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 530 D 555
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 530 and 555.
Details
Redox score ?
77
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
530
Residue number B
555
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 530 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 555 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 510 D 543
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 510 and 543.
Details
Redox score ?
76
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
510
Residue number B
543
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 510 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 543 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 632 A 639
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 632 and 639.
Details
Redox score ?
75
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
632
Residue number B
639
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 632 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 639 of Disintegrin and metalloproteinase domain-containing protein 10
5l0q D 555 D 562
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 555 and 562.
Details
Redox score ?
74
PDB code
5l0q
Structure name
crystal structure of the complex between adam10 d+c domain and a conformation specific mab 8c7
Structure deposition date
2016-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
555
Residue number B
562
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 555 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 562 of Disintegrin and metalloproteinase domain-containing protein 10
5l0q A 582 A 607
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 582 and 607.
Details
Redox score ?
72
PDB code
5l0q
Structure name
crystal structure of the complex between adam10 d+c domain and a conformation specific mab 8c7
Structure deposition date
2016-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
582
Residue number B
607
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 582 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 607 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 536 A 543
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 536 and 543.
Details
Redox score ?
71
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
536
Residue number B
543
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 536 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 543 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 530 D 567
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 530 and 567.
Details
Redox score ?
70
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
530
Residue number B
567
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 530 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 567 of Disintegrin and metalloproteinase domain-containing protein 10
6bdz A 597 A 607
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 597 and 607.
Details
Redox score ?
70
PDB code
6bdz
Structure name
adam10 extracellular domain bound by the 11g2 fab
Structure deposition date
2017-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
597
Residue number B
607
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 597 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 607 of Disintegrin and metalloproteinase domain-containing protein 10
5l0q D 594 D 632
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 594 and 632.
Details
Redox score ?
70
PDB code
5l0q
Structure name
crystal structure of the complex between adam10 d+c domain and a conformation specific mab 8c7
Structure deposition date
2016-07-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
594
Residue number B
632
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 594 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 632 of Disintegrin and metalloproteinase domain-containing protein 10
6bdz A 639 A 645
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 639 and 645.
Details
Redox score ?
69
PDB code
6bdz
Structure name
adam10 extracellular domain bound by the 11g2 fab
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
639
Residue number B
645
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 639 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 645 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 C 313 C 451
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 313 and 451.
Details
Redox score ?
68
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
313
Residue number B
451
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 313 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 451 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 473 A 484
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 473 and 484.
Details
Redox score ?
67
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
473
Residue number B
484
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 473 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 484 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 B 562 B 567
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 562 and 567.
Details
Redox score ?
66
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
562
Residue number B
567
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 562 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 567 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 483 D 511
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 483 and 511.
Details
Redox score ?
66
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
483
Residue number B
511
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 483 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 511 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 479 A 484
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 479 and 484.
Details
Redox score ?
65
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
479
Residue number B
484
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 479 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 484 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 B 484 B 495
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 484 and 495.
Details
Redox score ?
65
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
484
Residue number B
495
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 484 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 495 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 594 A 645
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 594 and 645.
Details
Redox score ?
64
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
594
Residue number B
645
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 594 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 645 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 D 511 D 515
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 511 and 515.
Details
Redox score ?
62
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
511
Residue number B
515
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 511 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 515 of Disintegrin and metalloproteinase domain-containing protein 10
6be6 A 503 A 515
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 503 and 515.
Details
Redox score ?
61
PDB code
6be6
Structure name
adam10 extracellular domain
Structure deposition date
2017-10-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
503
Residue number B
515
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 503 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 515 of Disintegrin and metalloproteinase domain-containing protein 10
6bdz A 483 A 503
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 483 and 503.
Details
Redox score ?
61
PDB code
6bdz
Structure name
adam10 extracellular domain bound by the 11g2 fab
Structure deposition date
2017-10-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14672
Residue number A
483
Residue number B
503
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 483 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 503 of Disintegrin and metalloproteinase domain-containing protein 10
2ao7 A 484 A 503
A redox-regulated disulphide may form within Disintegrin and metalloproteinase domain-containing protein 10 between cysteines 484 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
2ao7
Structure name
adam10 disintegrin and cysteine- rich domain
Structure deposition date
2005-08-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q10741
Residue number A
484
Residue number B
503
Peptide name
Disintegrin and metalloproteinase domain-containing protein 10
Ligandability
Cysteine 484 of Disintegrin and metalloproteinase domain-containing protein 10
Cysteine 503 of Disintegrin and metalloproteinase domain-containing protein 10
If this tool was useful for finding a disulphide, please cite: