a tool for identifying drug-targetable redox-active disulphides

Lysosomal cobalamin transporter ABCD4

Intramolecular

Cysteine 178 and cysteine 317

A redox-regulated disulphide may form within Lysosomal cobalamin transporter ABCD4 between cysteines 178 and 317.

Details

Redox score ?

78

PDB code

Structure name

cryo-em structure of human lysosomal cobalamin exporter abcd4

Structure deposition date

2019-01-25

Thiol separation (Å)

4

Half-sphere exposure sum ?

77

Minimum pK_a ?

7

% buried

62

Peptide accession

Residue number A

178

Residue number B

317

Peptide name

Lysosomal cobalamin transporter ABCD4

Ligandability

Cysteine 178 of Lysosomal cobalamin transporter ABCD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Lysosomal cobalamin transporter ABCD4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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