ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrin beta-1-binding protein 1

Intramolecular
Cysteine 143 and cysteine 184
Cysteine 143 and cysteine 174
Cysteine 174 and cysteine 184
A redox-regulated disulphide may form within Integrin beta-1-binding protein 1 between cysteines 143 and 184.

Details

Redox score ?
77
PDB code
4dx9
Structure name
icap1 in complex with integrin beta 1 cytoplasmic tail
Structure deposition date
2012-02-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
68
Peptide accession
O14713
Residue number A
143
Residue number B
184
Peptide name
Integrin beta-1-binding protein 1

Ligandability

Cysteine 143 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin beta-1-binding protein 1 between cysteines 143 and 174. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4dx9
Structure name
icap1 in complex with integrin beta 1 cytoplasmic tail
Structure deposition date
2012-02-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
90
Peptide accession
O14713
Residue number A
143
Residue number B
174
Peptide name
Integrin beta-1-binding protein 1

Ligandability

Cysteine 143 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin beta-1-binding protein 1 between cysteines 174 and 184. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4dx9
Structure name
icap1 in complex with integrin beta 1 cytoplasmic tail
Structure deposition date
2012-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
7
% buried
100
Peptide accession
O14713
Residue number A
174
Residue number B
184
Peptide name
Integrin beta-1-binding protein 1

Ligandability

Cysteine 174 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of Integrin beta-1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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