ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Inositol monophosphatase 2

Intramolecular
Cysteine 90 and cysteine 229 L
Cysteine 229 and cysteine 259
Cysteine 90 and cysteine 259 L
Cysteine 152 and cysteine 212
A redox-regulated disulphide may form within Inositol monophosphatase 2 between cysteines 90 and 229.

Details

Redox score ?
84
PDB code
2czh
Structure name
crystal structure of human myo-inositol monophosphatase 2 (impa2) with phosphate ion (orthorhombic form)
Structure deposition date
2005-07-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14732
Residue number A
90
Residue number B
229
Peptide name
Inositol monophosphatase 2

Ligandability

Cysteine 90 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 229 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol monophosphatase 2 between cysteines 229 and 259.

Details

Redox score ?
68
PDB code
2fvz
Structure name
human inositol monophosphosphatase 2
Structure deposition date
2006-01-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
nan
Peptide accession
O14732
Residue number A
229
Residue number B
259
Peptide name
Inositol monophosphatase 2

Ligandability

Cysteine 229 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol monophosphatase 2 between cysteines 90 and 259.

Details

Redox score ?
66
PDB code
2ddk
Structure name
crystal structure of human myo-inositol monophosphatase 2 (impa2) (orthorhombic form)
Structure deposition date
2006-01-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
nan
Peptide accession
O14732
Residue number A
90
Residue number B
259
Peptide name
Inositol monophosphatase 2

Ligandability

Cysteine 90 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inositol monophosphatase 2 between cysteines 152 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2czh
Structure name
crystal structure of human myo-inositol monophosphatase 2 (impa2) with phosphate ion (orthorhombic form)
Structure deposition date
2005-07-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
82
Peptide accession
O14732
Residue number A
152
Residue number B
212
Peptide name
Inositol monophosphatase 2

Ligandability

Cysteine 152 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Inositol monophosphatase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: