Telomerase reverse transcriptase
Intramolecular
Cysteine 403 and cysteine 468
Cysteine 982 and cysteine 1043
Cysteine 7 and cysteine 166
Cysteine 57 and cysteine 156
Cysteine 156 and cysteine 171
Cysteine 1043 and cysteine 1074
Cysteine 814 and cysteine 828
Cysteine 842 and cysteine 845
Cysteine 413 and cysteine 468
Cysteine 842 and cysteine 896
More...Cysteine 54 and cysteine 57
Cysteine 845 and cysteine 896
Cysteine 57 and cysteine 171
Cysteine 54 and cysteine 171
7tre A 403 A 468
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 403 and 468.
Details
Redox score ?
73
PDB code
7tre
Structure name
human telomerase catalytic core with shelterin protein tpp1
Structure deposition date
2022-01-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
90
Peptide accession
O14746
Residue number A
403
Residue number B
468
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 403 of Telomerase reverse transcriptase
Cysteine 468 of Telomerase reverse transcriptase
7qxa A 982 A 1043
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 982 and 1043.
Details
Redox score ?
73
PDB code
7qxa
Structure name
cryo-em map of human telomerase-dna-tpp1 complex (sharpened)
Structure deposition date
2022-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
100
Peptide accession
O14746
Residue number A
982
Residue number B
1043
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 982 of Telomerase reverse transcriptase
Cysteine 1043 of Telomerase reverse transcriptase
7qxa A 7 A 166
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 7 and 166. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7qxa
Structure name
cryo-em map of human telomerase-dna-tpp1 complex (sharpened)
Structure deposition date
2022-01-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
70
Peptide accession
O14746
Residue number A
7
Residue number B
166
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 7 of Telomerase reverse transcriptase
Cysteine 166 of Telomerase reverse transcriptase
7bg9 A 57 A 156
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 57 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7bg9
Structure name
the catalytic core lobe of human telomerase in complex with a telomeric dna substrate
Structure deposition date
2021-01-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
43
Peptide accession
O14746
Residue number A
57
Residue number B
156
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 57 of Telomerase reverse transcriptase
Cysteine 156 of Telomerase reverse transcriptase
7qxa A 156 A 171
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 156 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7qxa
Structure name
cryo-em map of human telomerase-dna-tpp1 complex (sharpened)
Structure deposition date
2022-01-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
87
Peptide accession
O14746
Residue number A
156
Residue number B
171
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 156 of Telomerase reverse transcriptase
Cysteine 171 of Telomerase reverse transcriptase
5ugw A 1043 A 1074
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 1043 and 1074. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5ugw
Structure name
structure of the human telomerase thumb domain
Structure deposition date
2017-01-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
83
Peptide accession
O14746
Residue number A
1043
Residue number B
1074
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 1043 of Telomerase reverse transcriptase
Cysteine 1074 of Telomerase reverse transcriptase
7bg9 A 814 A 828
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 814 and 828. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7bg9
Structure name
the catalytic core lobe of human telomerase in complex with a telomeric dna substrate
Structure deposition date
2021-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
8
Peptide accession
O14746
Residue number A
814
Residue number B
828
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 814 of Telomerase reverse transcriptase
Cysteine 828 of Telomerase reverse transcriptase
7qxs A 842 A 845
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 842 and 845. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7qxs
Structure name
cryo-em structure of human telomerase-dna-tpp1-pot1 complex (with pot1 side chains)
Structure deposition date
2022-01-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
90
Peptide accession
O14746
Residue number A
842
Residue number B
845
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 842 of Telomerase reverse transcriptase
Cysteine 845 of Telomerase reverse transcriptase
7trf A 413 A 468
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 413 and 468. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7trf
Structure name
human telomerase catalytic core rnp with h2a/h2b
Structure deposition date
2022-01-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
12
% buried
90
Peptide accession
O14746
Residue number A
413
Residue number B
468
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 413 of Telomerase reverse transcriptase
Cysteine 468 of Telomerase reverse transcriptase
7qxs A 842 A 896
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 842 and 896. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7qxs
Structure name
cryo-em structure of human telomerase-dna-tpp1-pot1 complex (with pot1 side chains)
Structure deposition date
2022-01-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
90
Peptide accession
O14746
Residue number A
842
Residue number B
896
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 842 of Telomerase reverse transcriptase
Cysteine 896 of Telomerase reverse transcriptase
7tre A 54 A 57
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 54 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7tre
Structure name
human telomerase catalytic core with shelterin protein tpp1
Structure deposition date
2022-01-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
92
Peptide accession
O14746
Residue number A
54
Residue number B
57
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 54 of Telomerase reverse transcriptase
Cysteine 57 of Telomerase reverse transcriptase
7tre A 845 A 896
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 845 and 896. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
7tre
Structure name
human telomerase catalytic core with shelterin protein tpp1
Structure deposition date
2022-01-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
80
Peptide accession
O14746
Residue number A
845
Residue number B
896
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 845 of Telomerase reverse transcriptase
Cysteine 896 of Telomerase reverse transcriptase
7qxs A 57 A 171
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 57 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
7qxs
Structure name
cryo-em structure of human telomerase-dna-tpp1-pot1 complex (with pot1 side chains)
Structure deposition date
2022-01-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
90
Peptide accession
O14746
Residue number A
57
Residue number B
171
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 57 of Telomerase reverse transcriptase
Cysteine 171 of Telomerase reverse transcriptase
7tre A 54 A 171
A redox-regulated disulphide may form within Telomerase reverse transcriptase between cysteines 54 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
7tre
Structure name
human telomerase catalytic core with shelterin protein tpp1
Structure deposition date
2022-01-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
100
Peptide accession
O14746
Residue number A
54
Residue number B
171
Peptide name
Telomerase reverse transcriptase
Ligandability
Cysteine 54 of Telomerase reverse transcriptase
Cysteine 171 of Telomerase reverse transcriptase
If this tool was useful for finding a disulphide, please cite: