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Tumor necrosis factor receptor superfamily member 10B

Intermolecular
Cysteine 232 and cysteine 232
Intramolecular
Cysteine 156 and cysteine 170
Cysteine 160 and cysteine 178
Cysteine 97 and cysteine 113
Cysteine 119 and cysteine 137
Cysteine 81 and cysteine 94
Cysteine 116 and cysteine 129
Cysteine 139 and cysteine 153
Cysteine 97 and cysteine 116
Cysteine 153 and cysteine 170
More...
Cysteine 94 and cysteine 113
Cysteine 97 and cysteine 129
Cysteine 113 and cysteine 116
Cysteine 129 and cysteine 137
Cysteine 139 and cysteine 156
Cysteine 137 and cysteine 139
Cysteine 139 and cysteine 170
Cysteine 156 and cysteine 160
Cysteine 94 and cysteine 97
Cysteine 156 and cysteine 178
Cysteine 81 and cysteine 113
Cysteine 137 and cysteine 153
Cysteine 113 and cysteine 129
Cysteine 119 and cysteine 139
Cysteine 81 and cysteine 97
Cysteine 170 and cysteine 178
Cysteine 116 and cysteine 137
Cysteine 119 and cysteine 129
Cysteine 116 and cysteine 119
Cysteine 160 and cysteine 170
Cysteine 153 and cysteine 156
Cysteine 119 and cysteine 153
A redox-regulated disulphide may form between two units of Tumor necrosis factor receptor superfamily member 10B at cysteines 232 and 232.

Details

Redox score ?
68
PDB code
6nhw
Structure name
structure of the transmembrane domain of the death receptor 5 - dimer of trimer
Structure deposition date
2018-12-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide A name
Tumor necrosis factor receptor superfamily member 10B
Peptide B name
Tumor necrosis factor receptor superfamily member 10B
Peptide A accession
O14763
Peptide B accession
O14763
Peptide A residue number
232
Peptide B residue number
232

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 156 and 170 (103 and 117 respectively in this structure).

Details

Redox score ?
89
PDB code
4n90
Structure name
crystal structure of ternary complex of trail, dr5, and fab fragment from a dr5 agonist antibody
Structure deposition date
2013-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
156
Residue number B
170
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 156 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 160 and 178 (107 and 125 respectively in this structure).

Details

Redox score ?
89
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
160
Residue number B
178
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 160 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 97 and 113.

Details

Redox score ?
88
PDB code
4i9x
Structure name
crystal structure of human cytomegalovirus glycoprotein ul141 targeting the death receptor trail-r2
Structure deposition date
2012-12-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
97
Residue number B
113
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 97 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 119 and 137.

Details

Redox score ?
86
PDB code
6t3j
Structure name
dual epitope targeting by anti-dr5 antibodies
Structure deposition date
2019-10-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
119
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 119 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 81 and 94 (28 and 41 respectively in this structure).

Details

Redox score ?
86
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
81
Residue number B
94
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 81 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 94 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 116 and 129 (63 and 76 respectively in this structure).

Details

Redox score ?
84
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
116
Residue number B
129
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 116 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 139 and 153 (86 and 100 respectively in this structure).

Details

Redox score ?
83
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
139
Residue number B
153
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 139 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 97 and 116 (44 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4od2
Structure name
crystal structure of the fab fragment of an anti-dr5 antibody bound to dr5
Structure deposition date
2014-01-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
97
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 97 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 153 and 170 (100 and 117 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2h9g
Structure name
crystal structure of phage derived fab bdf1 with human death receptor 5 (dr5)
Structure deposition date
2006-06-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
153
Residue number B
170
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 153 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 94 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
94
Residue number B
113
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 94 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 97 and 129 (44 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
97
Residue number B
129
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 97 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 113 and 116 (60 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
113
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 113 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 129 and 137 (76 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
129
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 129 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 139 and 156 (86 and 103 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
139
Residue number B
156
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 139 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 137 and 139 (84 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2h9g
Structure name
crystal structure of phage derived fab bdf1 with human death receptor 5 (dr5)
Structure deposition date
2006-06-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
137
Residue number B
139
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 137 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 139 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6t3j
Structure name
dual epitope targeting by anti-dr5 antibodies
Structure deposition date
2019-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
139
Residue number B
170
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 139 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 156 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
156
Residue number B
160
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 156 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 94 and 97. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
94
Residue number B
97
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 94 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 156 and 178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
156
Residue number B
178
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 156 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 81 and 113 (28 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
81
Residue number B
113
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 81 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 137 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6t3j
Structure name
dual epitope targeting by anti-dr5 antibodies
Structure deposition date
2019-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
137
Residue number B
153
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 137 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 113 and 129 (60 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4od2
Structure name
crystal structure of the fab fragment of an anti-dr5 antibody bound to dr5
Structure deposition date
2014-01-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
113
Residue number B
129
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 113 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 119 and 139 (66 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2h9g
Structure name
crystal structure of phage derived fab bdf1 with human death receptor 5 (dr5)
Structure deposition date
2006-06-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
119
Residue number B
139
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 119 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 81 and 97 (28 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
81
Residue number B
97
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 81 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 170 and 178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
170
Residue number B
178
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 116 and 137 (63 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
116
Residue number B
137
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 116 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 119 and 129 (66 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
119
Residue number B
129
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 119 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 116 and 119 (63 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1du3
Structure name
crystal structure of trail-sdr5
Structure deposition date
2000-01-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
116
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 116 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 160 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
8dpx
Structure name
preligand association structure of dr5
Structure deposition date
2022-07-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
160
Residue number B
170
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 160 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 170 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 153 and 156 (100 and 103 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1d0g
Structure name
crystal structure of death receptor 5 (dr5) bound to apo2l/trail
Structure deposition date
1999-09-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
153
Residue number B
156
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 153 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 10B between cysteines 119 and 153 (66 and 100 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4n90
Structure name
crystal structure of ternary complex of trail, dr5, and fab fragment from a dr5 agonist antibody
Structure deposition date
2013-10-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O14763
Residue number A
119
Residue number B
153
Peptide name
Tumor necrosis factor receptor superfamily member 10B

Ligandability

Cysteine 119 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Tumor necrosis factor receptor superfamily member 10B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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