a tool for identifying drug-targetable redox-active disulphides

Gamma-aminobutyric acid receptor subunit delta

Intramolecular

Cysteine 164 and cysteine 178

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit delta between cysteines 164 and 178.

Details

Redox score ?

85

PDB code

Structure name

cryo-em structure of human full-length beta3delta gaba(a)r in complex with histamine and nanobody nb25

Structure deposition date

2021-12-20

Thiol separation (Å)

2

Half-sphere exposure sum ?

66

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

164

Residue number B

178

Peptide name

Gamma-aminobutyric acid receptor subunit delta

Ligandability

Cysteine 164 of Gamma-aminobutyric acid receptor subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Gamma-aminobutyric acid receptor subunit delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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