a tool for identifying drug-targetable redox-active disulphides

Heparan sulfate glucosamine 3-O-sulfotransferase 1

Intramolecular

Cysteine 260 and cysteine 269

A redox-regulated disulphide may form within Heparan sulfate glucosamine 3-O-sulfotransferase 1 between cysteines 260 and 269.

Details

Redox score ?

81

PDB code

Structure name

crystal structure of 3-o-sulfotransferase (3-ost-1) with bound pap and heptasaccharide substrate

Structure deposition date

2011-10-21

Thiol separation (Å)

2

Half-sphere exposure sum ?

62

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

260

Residue number B

269

Peptide name

Heparan sulfate glucosamine 3-O-sulfotransferase 1

Ligandability

Cysteine 260 of Heparan sulfate glucosamine 3-O-sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Heparan sulfate glucosamine 3-O-sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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