DNA-directed RNA polymerase III subunit RPC1
Intermolecular
Cysteine 1126 and cysteine 20 of DNA-directed RNA polymerase III subunit RPC10
Cysteine 113 and cysteine 79 of DNA-directed RNA polymerase III subunit RPC3
Cysteine 19 and cysteine 1110 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 72 and cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
Cysteine 565 and cysteine 68 of DNA-directed RNA polymerases I and III subunit RPAC2
Intramolecular
Cysteine 72 and cysteine 79
Cysteine 69 and cysteine 79
Cysteine 625 and cysteine 632
Cysteine 112 and cysteine 156
Cysteine 109 and cysteine 156
More...Cysteine 69 and cysteine 72
Cysteine 156 and cysteine 159
Cysteine 92 and cysteine 317
Cysteine 112 and cysteine 159
Cysteine 960 and cysteine 961
Cysteine 109 and cysteine 150
Cysteine 109 and cysteine 113
Cysteine 150 and cysteine 159
Cysteine 79 and cysteine 261
Cysteine 109 and cysteine 159
Cysteine 1341 and cysteine 1346
Cysteine 112 and cysteine 113
Cysteine 72 and cysteine 261
Cysteine 19 and cysteine 1341
Cysteine 69 and cysteine 261
Cysteine 113 and cysteine 159
Cysteine 150 and cysteine 156
Cysteine 109 and cysteine 112
Cysteine 112 and cysteine 150
Cysteine 113 and cysteine 156
Cysteine 961 and cysteine 1018
Cysteine 491 and cysteine 493
Cysteine 767 and cysteine 798
7d59 A 1126 I 20
A redox-regulated disulphide may form between cysteine 1126 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 20 of DNA-directed RNA polymerase III subunit RPC10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
30
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC10
Peptide A accession
O14802
Peptide B accession
Q9Y2Y1
Peptide A residue number
1126
Peptide B residue number
20
Ligandability
Cysteine 1126 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 20 of DNA-directed RNA polymerase III subunit RPC10
7ast N 113 X 79
A redox-regulated disulphide may form between cysteine 113 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 79 of DNA-directed RNA polymerase III subunit RPC3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC3
Peptide A accession
O14802
Peptide B accession
Q9BUI4
Peptide A residue number
113
Peptide B residue number
79
Ligandability
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 79 of DNA-directed RNA polymerase III subunit RPC3
7ast N 19 M 1110
A redox-regulated disulphide may form between cysteine 19 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1110 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
80
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
O14802
Peptide B accession
Q9NW08
Peptide A residue number
19
Peptide B residue number
1110
Ligandability
Cysteine 19 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1110 of DNA-directed RNA polymerase III subunit RPC2
7ast N 72 M 1092
A redox-regulated disulphide may form between cysteine 72 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
72
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerase III subunit RPC2
Peptide A accession
O14802
Peptide B accession
Q9NW08
Peptide A residue number
72
Peptide B residue number
1092
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1092 of DNA-directed RNA polymerase III subunit RPC2
7dn3 A 565 K 68
A redox-regulated disulphide may form between cysteine 565 of DNA-directed RNA polymerase III subunit RPC1 and cysteine 68 of DNA-directed RNA polymerases I and III subunit RPAC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC1
Peptide B name
DNA-directed RNA polymerases I and III subunit RPAC2
Peptide A accession
O14802
Peptide B accession
P0DPB6
Peptide A residue number
565
Peptide B residue number
68
Ligandability
Cysteine 565 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 68 of DNA-directed RNA polymerases I and III subunit RPAC2
7ae1 A 72 A 79
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 72 and 79.
Details
Redox score ?
94
PDB code
7ae1
Structure name
cryo-em structure of human rna polymerase iii elongation complex 1
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
0
% buried
62
Peptide accession
O14802
Residue number A
72
Residue number B
79
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 79 of DNA-directed RNA polymerase III subunit RPC1
7d59 A 69 A 79
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 69 and 79.
Details
Redox score ?
91
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
2
% buried
56
Peptide accession
O14802
Residue number A
69
Residue number B
79
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 79 of DNA-directed RNA polymerase III subunit RPC1
7dn3 A 625 A 632
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 625 and 632.
Details
Redox score ?
80
PDB code
7dn3
Structure name
structure of human rna polymerase iii elongation complex
Structure deposition date
2020-12-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
34
Peptide accession
O14802
Residue number A
625
Residue number B
632
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 625 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 632 of DNA-directed RNA polymerase III subunit RPC1
7fji A 112 A 156
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 112 and 156.
Details
Redox score ?
80
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
4
% buried
74
Peptide accession
O14802
Residue number A
112
Residue number B
156
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 112 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 156 of DNA-directed RNA polymerase III subunit RPC1
7a6h A 109 A 156
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 109 and 156.
Details
Redox score ?
80
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
4
% buried
nan
Peptide accession
O14802
Residue number A
109
Residue number B
156
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 109 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 156 of DNA-directed RNA polymerase III subunit RPC1
7ae1 A 69 A 72
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 69 and 72.
Details
Redox score ?
74
PDB code
7ae1
Structure name
cryo-em structure of human rna polymerase iii elongation complex 1
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
54
Peptide accession
O14802
Residue number A
69
Residue number B
72
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1
7aea A 156 A 159
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 156 and 159.
Details
Redox score ?
66
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
13
% buried
nan
Peptide accession
O14802
Residue number A
156
Residue number B
159
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 156 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 159 of DNA-directed RNA polymerase III subunit RPC1
7fji A 92 A 317
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 92 and 317.
Details
Redox score ?
65
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
O14802
Residue number A
92
Residue number B
317
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 92 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 317 of DNA-directed RNA polymerase III subunit RPC1
7fjj A 112 A 159
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 112 and 159.
Details
Redox score ?
65
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
14
% buried
76
Peptide accession
O14802
Residue number A
112
Residue number B
159
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 112 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 159 of DNA-directed RNA polymerase III subunit RPC1
7aea A 960 A 961
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 960 and 961. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
30
Peptide accession
O14802
Residue number A
960
Residue number B
961
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 960 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 961 of DNA-directed RNA polymerase III subunit RPC1
7d59 A 109 A 150
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 109 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
5
% buried
75
Peptide accession
O14802
Residue number A
109
Residue number B
150
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 109 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 150 of DNA-directed RNA polymerase III subunit RPC1
7a6h A 109 A 113
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 109 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
4
% buried
93
Peptide accession
O14802
Residue number A
109
Residue number B
113
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 109 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1
7ast N 150 N 159
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 150 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
nan
Peptide accession
O14802
Residue number A
150
Residue number B
159
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 150 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 159 of DNA-directed RNA polymerase III subunit RPC1
7fjj A 79 A 261
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 79 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
88
Peptide accession
O14802
Residue number A
79
Residue number B
261
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 79 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 261 of DNA-directed RNA polymerase III subunit RPC1
7d58 A 109 A 159
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 109 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7d58
Structure name
cryo-em structure of human rna polymerase iii in elongating state
Structure deposition date
2020-09-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
60
Peptide accession
O14802
Residue number A
109
Residue number B
159
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 109 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 159 of DNA-directed RNA polymerase III subunit RPC1
7fji A 1341 A 1346
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 1341 and 1346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
84
Peptide accession
O14802
Residue number A
1341
Residue number B
1346
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 1341 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1346 of DNA-directed RNA polymerase III subunit RPC1
7ast N 112 N 113
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 112 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
90
Peptide accession
O14802
Residue number A
112
Residue number B
113
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 112 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1
7ast N 72 N 261
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 72 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
99
Peptide accession
O14802
Residue number A
72
Residue number B
261
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 72 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 261 of DNA-directed RNA polymerase III subunit RPC1
7ast N 19 N 1341
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 19 and 1341. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
56
Peptide accession
O14802
Residue number A
19
Residue number B
1341
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 19 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1341 of DNA-directed RNA polymerase III subunit RPC1
7du2 A 69 A 261
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 69 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
nan
Peptide accession
O14802
Residue number A
69
Residue number B
261
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 69 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 261 of DNA-directed RNA polymerase III subunit RPC1
7ast N 113 N 159
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 113 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
nan
Peptide accession
O14802
Residue number A
113
Residue number B
159
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 159 of DNA-directed RNA polymerase III subunit RPC1
7d59 A 150 A 156
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 150 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7d59
Structure name
cryo-em structure of human rna polymerase iii in apo state
Structure deposition date
2020-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
52
Peptide accession
O14802
Residue number A
150
Residue number B
156
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 150 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 156 of DNA-directed RNA polymerase III subunit RPC1
7aea A 109 A 112
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 109 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
22
% buried
nan
Peptide accession
O14802
Residue number A
109
Residue number B
112
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 109 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 112 of DNA-directed RNA polymerase III subunit RPC1
7ast N 112 N 150
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 112 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7ast
Structure name
apo human rna polymerase iii
Structure deposition date
2020-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
51
Peptide accession
O14802
Residue number A
112
Residue number B
150
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 112 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 150 of DNA-directed RNA polymerase III subunit RPC1
7du2 A 113 A 156
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 113 and 156. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7du2
Structure name
rna polymerase iii ec complex in post-translocation state
Structure deposition date
2021-01-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
78
Peptide accession
O14802
Residue number A
113
Residue number B
156
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 113 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 156 of DNA-directed RNA polymerase III subunit RPC1
7fji A 961 A 1018
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 961 and 1018. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
76
Peptide accession
O14802
Residue number A
961
Residue number B
1018
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 961 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 1018 of DNA-directed RNA polymerase III subunit RPC1
7fji A 491 A 493
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 491 and 493. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
O14802
Residue number A
491
Residue number B
493
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 491 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 493 of DNA-directed RNA polymerase III subunit RPC1
7a6h A 767 A 798
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC1 between cysteines 767 and 798. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
78
Peptide accession
O14802
Residue number A
767
Residue number B
798
Peptide name
DNA-directed RNA polymerase III subunit RPC1
Ligandability
Cysteine 767 of DNA-directed RNA polymerase III subunit RPC1
Cysteine 798 of DNA-directed RNA polymerase III subunit RPC1
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