ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phytanoyl-CoA dioxygenase, peroxisomal

Intramolecular
Cysteine 134 and cysteine 280
Cysteine 191 and cysteine 280
A redox-regulated disulphide may form within Phytanoyl-CoA dioxygenase, peroxisomal between cysteines 134 and 280.

Details

Redox score ?
68
PDB code
2a1x
Structure name
human phytanoyl-coa 2-hydroxylase in complex with iron and 2- oxoglutarate
Structure deposition date
2005-06-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
O14832
Residue number A
134
Residue number B
280
Peptide name
Phytanoyl-CoA dioxygenase, peroxisomal

Ligandability

Cysteine 134 of Phytanoyl-CoA dioxygenase, peroxisomal

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Phytanoyl-CoA dioxygenase, peroxisomal

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phytanoyl-CoA dioxygenase, peroxisomal between cysteines 191 and 280. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2a1x
Structure name
human phytanoyl-coa 2-hydroxylase in complex with iron and 2- oxoglutarate
Structure deposition date
2005-06-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
O14832
Residue number A
191
Residue number B
280
Peptide name
Phytanoyl-CoA dioxygenase, peroxisomal

Ligandability

Cysteine 191 of Phytanoyl-CoA dioxygenase, peroxisomal

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Phytanoyl-CoA dioxygenase, peroxisomal

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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