ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription regulator protein BACH1

Intramolecular
Cysteine 107 and cysteine 122
Cysteine 107 and cysteine 109
A redox-regulated disulphide may form within Transcription regulator protein BACH1 between cysteines 107 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2ihc
Structure name
crystal structure of the bric-a-brac (btb) domain of human bach1
Structure deposition date
2006-09-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
35
Peptide accession
O14867
Residue number A
107
Residue number B
122
Peptide name
Transcription regulator protein BACH1

Ligandability

Cysteine 107 of Transcription regulator protein BACH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Transcription regulator protein BACH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription regulator protein BACH1 between cysteines 107 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2ihc
Structure name
crystal structure of the bric-a-brac (btb) domain of human bach1
Structure deposition date
2006-09-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
34
Peptide accession
O14867
Residue number A
107
Residue number B
109
Peptide name
Transcription regulator protein BACH1

Ligandability

Cysteine 107 of Transcription regulator protein BACH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Transcription regulator protein BACH1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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