ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peripheral plasma membrane protein CASK

Intramolecular
Cysteine 15 and cysteine 29
Cysteine 66 and cysteine 132
Cysteine 132 and cysteine 205
A redox-regulated disulphide may form within Peripheral plasma membrane protein CASK between cysteines 15 and 29. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3c0i
Structure name
cask cam-kinase domain- 3'-amp complex, p212121 form
Structure deposition date
2008-01-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
32
Peptide accession
O14936
Residue number A
15
Residue number B
29
Peptide name
Peripheral plasma membrane protein CASK

Ligandability

Cysteine 15 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 29 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peripheral plasma membrane protein CASK between cysteines 66 and 132. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3c0h
Structure name
cask cam-kinase domain- amppnp complex, p1 form
Structure deposition date
2008-01-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
92
Peptide accession
O14936
Residue number A
66
Residue number B
132
Peptide name
Peripheral plasma membrane protein CASK

Ligandability

Cysteine 66 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peripheral plasma membrane protein CASK between cysteines 132 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
6lnm
Structure name
crystal structure of cask-camk in complex with mint1-cid
Structure deposition date
2019-12-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q62915
Residue number A
132
Residue number B
205
Peptide name
Peripheral plasma membrane protein CASK

Ligandability

Cysteine 132 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Peripheral plasma membrane protein CASK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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