Hepatocyte growth factor-regulated tyrosine kinase substrate
Intramolecular
Cysteine 166 and cysteine 169
Cysteine 166 and cysteine 193
Cysteine 166 and cysteine 190
Cysteine 212 and cysteine 215
Cysteine 169 and cysteine 193
Cysteine 182 and cysteine 215
Cysteine 169 and cysteine 190
Cysteine 185 and cysteine 215 L
Cysteine 32 and cysteine 75
Cysteine 190 and cysteine 193
More...Cysteine 182 and cysteine 212
Cysteine 185 and cysteine 212 L
Cysteine 166 and cysteine 212
Cysteine 182 and cysteine 185 L
Cysteine 193 and cysteine 212
4avx A 166 A 169
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 166 and 169.
Details
Redox score ?
87
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
5
% buried
12
Peptide accession
O14964
Residue number A
166
Residue number B
169
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 166 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 169 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 166 A 193
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 166 and 193.
Details
Redox score ?
86
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
5
% buried
18
Peptide accession
O14964
Residue number A
166
Residue number B
193
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 166 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 193 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 166 A 190
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 166 and 190.
Details
Redox score ?
83
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
20
Peptide accession
O14964
Residue number A
166
Residue number B
190
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 166 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 190 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 212 A 215
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 212 and 215.
Details
Redox score ?
82
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
46
Peptide accession
O14964
Residue number A
212
Residue number B
215
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 212 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 215 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 169 A 193
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 169 and 193.
Details
Redox score ?
80
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
6
Peptide accession
O14964
Residue number A
169
Residue number B
193
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 169 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 193 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 182 A 215
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 182 and 215.
Details
Redox score ?
80
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
nan
Peptide accession
O14964
Residue number A
182
Residue number B
215
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 182 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 215 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 169 A 190
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 169 and 190.
Details
Redox score ?
78
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
8
Peptide accession
O14964
Residue number A
169
Residue number B
190
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 169 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 190 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 185 A 215
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 185 and 215.
Details
Redox score ?
78
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
50
Peptide accession
O14964
Residue number A
185
Residue number B
215
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 185 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 215 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 32 A 75
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 32 and 75.
Details
Redox score ?
77
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
56
Peptide accession
O14964
Residue number A
32
Residue number B
75
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 32 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 75 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 190 A 193
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 190 and 193.
Details
Redox score ?
75
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
14
Peptide accession
O14964
Residue number A
190
Residue number B
193
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 190 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 193 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 182 A 212
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 182 and 212.
Details
Redox score ?
63
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
14
% buried
nan
Peptide accession
O14964
Residue number A
182
Residue number B
212
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 182 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 212 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 185 A 212
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 185 and 212.
Details
Redox score ?
60
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
14
% buried
48
Peptide accession
O14964
Residue number A
185
Residue number B
212
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 185 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 212 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 166 A 212
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 166 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
5
% buried
34
Peptide accession
O14964
Residue number A
166
Residue number B
212
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 166 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 212 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 182 A 185
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 182 and 185. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
22
% buried
nan
Peptide accession
O14964
Residue number A
182
Residue number B
185
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 182 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 185 of Hepatocyte growth factor-regulated tyrosine kinase substrate
4avx A 193 A 212
A redox-regulated disulphide may form within Hepatocyte growth factor-regulated tyrosine kinase substrate between cysteines 193 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4avx
Structure name
hepatocyte growth factor-regulated tyrosine kinase substrate (hgs-hrs) bound to an ip2 compound at 1
Structure deposition date
2012-05-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
12
% buried
28
Peptide accession
O14964
Residue number A
193
Residue number B
212
Peptide name
Hepatocyte growth factor-regulated tyrosine kinase substrate
Ligandability
Cysteine 193 of Hepatocyte growth factor-regulated tyrosine kinase substrate
Cysteine 212 of Hepatocyte growth factor-regulated tyrosine kinase substrate
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