ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cyclin-G-associated kinase

Intermolecular
Cysteine 87 and cysteine 87 L
Intramolecular
Cysteine 145 and cysteine 257
Cysteine 126 and cysteine 190 L
A redox-regulated disulphide may form between two units of Cyclin-G-associated kinase at cysteines 87 and 87.

Details

Redox score ?
80
PDB code
4c57
Structure name
structure of gak kinase in complex with a nanobody
Structure deposition date
2013-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cyclin-G-associated kinase
Peptide B name
Cyclin-G-associated kinase
Peptide A accession
O14976
Peptide B accession
O14976
Peptide A residue number
87
Peptide B residue number
87

Ligandability

Not ligandable in the dataset of Yang et al.

Ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclin-G-associated kinase between cysteines 145 and 257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4c57
Structure name
structure of gak kinase in complex with a nanobody
Structure deposition date
2013-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
59
Peptide accession
O14976
Residue number A
145
Residue number B
257
Peptide name
Cyclin-G-associated kinase

Ligandability

Cysteine 145 of Cyclin-G-associated kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Cyclin-G-associated kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cyclin-G-associated kinase between cysteines 126 and 190. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4c57
Structure name
structure of gak kinase in complex with a nanobody
Structure deposition date
2013-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
100
Peptide accession
O14976
Residue number A
126
Residue number B
190
Peptide name
Cyclin-G-associated kinase

Ligandability

Cysteine 126 of Cyclin-G-associated kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Cyclin-G-associated kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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