ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Antizyme inhibitor 1

Intermolecular
Cysteine 114 and cysteine 358
Intramolecular
Cysteine 177 and cysteine 217
Cysteine 133 and cysteine 183
Cysteine 133 and cysteine 177
A redox-regulated disulphide may form between two units of Antizyme inhibitor 1 at cysteines 114 and 358.

Details

Redox score ?
65
PDB code
3btn
Structure name
crystal structure of antizyme inhibitor, an ornithine decarboxylase homologous protein
Structure deposition date
2007-12-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
90
Peptide A name
Antizyme inhibitor 1
Peptide B name
Antizyme inhibitor 1
Peptide A accession
O35484
Peptide B accession
O35484
Peptide A residue number
114
Peptide B residue number
358

Ligandability

Cysteine 114 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Antizyme inhibitor 1 between cysteines 177 and 217. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
3btn
Structure name
crystal structure of antizyme inhibitor, an ornithine decarboxylase homologous protein
Structure deposition date
2007-12-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
44
Peptide accession
O35484
Residue number A
177
Residue number B
217
Peptide name
Antizyme inhibitor 1

Ligandability

Cysteine 177 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Antizyme inhibitor 1 between cysteines 133 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3btn
Structure name
crystal structure of antizyme inhibitor, an ornithine decarboxylase homologous protein
Structure deposition date
2007-12-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
58
Peptide accession
O35484
Residue number A
133
Residue number B
183
Peptide name
Antizyme inhibitor 1

Ligandability

Cysteine 133 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Antizyme inhibitor 1 between cysteines 133 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
3btn
Structure name
crystal structure of antizyme inhibitor, an ornithine decarboxylase homologous protein
Structure deposition date
2007-12-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
87
Peptide accession
O35484
Residue number A
133
Residue number B
177
Peptide name
Antizyme inhibitor 1

Ligandability

Cysteine 133 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Antizyme inhibitor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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