ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Exportin-1

Intermolecular
Cysteine 723 and cysteine 356 of Snurportin-1
Intramolecular
Cysteine 164 and cysteine 209 L
Cysteine 327 and cysteine 369
Cysteine 209 and cysteine 267
A redox-regulated disulphide may form between cysteine 723 of Exportin-1 and cysteine 356 of Snurportin-1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
3nc0
Structure name
crystal structure of the hiv-1 rev nes-crm1-rangtp nuclear export complex (crystal ii)
Structure deposition date
2010-06-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
78
Peptide A name
Exportin-1
Peptide B name
Snurportin-1
Peptide A accession
Q6P5F9
Peptide B accession
O95149
Peptide A residue number
723
Peptide B residue number
356

Ligandability

Cysteine 723 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Snurportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-1 between cysteines 164 and 209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4bsn
Structure name
crystal structure of the nuclear export receptor crm1 (exportin-1) lacking the c-terminal helical extension at 4
Structure deposition date
2013-06-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
78
Peptide accession
O14980
Residue number A
164
Residue number B
209
Peptide name
Exportin-1

Ligandability

Cysteine 164 of Exportin-1

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-1 between cysteines 327 and 369. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3nbz
Structure name
crystal structure of the hiv-1 rev nes-crm1-rangtp nuclear export complex (crystal i)
Structure deposition date
2010-06-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
98
Peptide accession
Q6P5F9
Residue number A
327
Residue number B
369
Peptide name
Exportin-1

Ligandability

Cysteine 327 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 369 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-1 between cysteines 209 and 267. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4bsn
Structure name
crystal structure of the nuclear export receptor crm1 (exportin-1) lacking the c-terminal helical extension at 4
Structure deposition date
2013-06-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
100
Peptide accession
O14980
Residue number A
209
Residue number B
267
Peptide name
Exportin-1

Ligandability

Cysteine 209 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 267 of Exportin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: