ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Plexin-B2

Intermolecular
Cysteine 1508 and cysteine 1508 L
Cysteine 1510 and cysteine 1510 L
Intramolecular
Cysteine 1508 and cysteine 1510 L
A redox-regulated disulphide may form between two units of Plexin-B2 at cysteines 1508 and 1508.

Details

Redox score ?
83
PDB code
7kdc
Structure name
the complex between rhod and the plexin b2 rbd
Structure deposition date
2020-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide A name
Plexin-B2
Peptide B name
Plexin-B2
Peptide A accession
B2RXS4
Peptide B accession
B2RXS4
Peptide A residue number
1508
Peptide B residue number
1508

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Plexin-B2 at cysteines 1510 and 1510.

Details

Redox score ?
75
PDB code
7kdc
Structure name
the complex between rhod and the plexin b2 rbd
Structure deposition date
2020-10-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide A name
Plexin-B2
Peptide B name
Plexin-B2
Peptide A accession
B2RXS4
Peptide B accession
B2RXS4
Peptide A residue number
1510
Peptide B residue number
1510

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plexin-B2 between cysteines 1508 and 1510. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5e6p
Structure name
plexinb2 cytoplasmic region/pdz-rhogef pdz domain complex
Structure deposition date
2015-10-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
19
Peptide accession
B2RXS4
Residue number A
1508
Residue number B
1510
Peptide name
Plexin-B2

Ligandability

Cysteine 1508 of Plexin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 1510 of Plexin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: