Period circadian protein homolog 2
Intermolecular
Cysteine 414 of Cryptochrome-1 and cysteine 1210
Cysteine 432 of Cryptochrome-2 and cysteine 1210
Cysteine 414 of Cryptochrome-1 and cysteine 1213
Cysteine 432 of Cryptochrome-2 and cysteine 1213
Cysteine 412 of Cryptochrome-1 and cysteine 1210
Cysteine 430 of Cryptochrome-2 and cysteine 1210
Cysteine 363 of Cryptochrome-1 and cysteine 1210
Cysteine 430 of Cryptochrome-2 and cysteine 1213
Cysteine 381 of Cryptochrome-2 and cysteine 1210
Intramolecular
Cysteine 1210 and cysteine 1213
Cysteine 307 and cysteine 308
4ct0 A 414 B 1210
A redox-regulated disulphide may form between cysteine 414 of Cryptochrome-1 and cysteine 1210 of Period circadian protein homolog 2.
Details
Redox score ?
88
PDB code
4ct0
Structure name
crystal structure of mouse cryptochrome1 in complex with period2
Structure deposition date
2014-03-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
74
Minimum pKa ?
2
% buried
66
Peptide A name
Cryptochrome-1
Peptide B name
Period circadian protein homolog 2
Peptide A accession
P97784
Peptide B accession
O54943
Peptide A residue number
414
Peptide B residue number
1210
Ligandability
Cysteine 414 of Cryptochrome-1
Cysteine 1210 of Period circadian protein homolog 2
4u8h A 432 B 1210
A redox-regulated disulphide may form between cysteine 432 of Cryptochrome-2 and cysteine 1210 of Period circadian protein homolog 2.
Details
Redox score ?
83
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
1
% buried
71
Peptide A name
Cryptochrome-2
Peptide B name
Period circadian protein homolog 2
Peptide A accession
Q9R194
Peptide B accession
O54943
Peptide A residue number
432
Peptide B residue number
1210
Ligandability
Cysteine 432 of Cryptochrome-2
Cysteine 1210 of Period circadian protein homolog 2
4ct0 A 414 B 1213
A redox-regulated disulphide may form between cysteine 414 of Cryptochrome-1 and cysteine 1213 of Period circadian protein homolog 2.
Details
Redox score ?
75
PDB code
4ct0
Structure name
crystal structure of mouse cryptochrome1 in complex with period2
Structure deposition date
2014-03-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
57
Peptide A name
Cryptochrome-1
Peptide B name
Period circadian protein homolog 2
Peptide A accession
P97784
Peptide B accession
O54943
Peptide A residue number
414
Peptide B residue number
1213
Ligandability
Cysteine 414 of Cryptochrome-1
Cysteine 1213 of Period circadian protein homolog 2
4u8h A 432 B 1213
A redox-regulated disulphide may form between cysteine 432 of Cryptochrome-2 and cysteine 1213 of Period circadian protein homolog 2.
Details
Redox score ?
69
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
60
Peptide A name
Cryptochrome-2
Peptide B name
Period circadian protein homolog 2
Peptide A accession
Q9R194
Peptide B accession
O54943
Peptide A residue number
432
Peptide B residue number
1213
Ligandability
Cysteine 432 of Cryptochrome-2
Cysteine 1213 of Period circadian protein homolog 2
4ct0 A 412 B 1210
A redox-regulated disulphide may form between cysteine 412 of Cryptochrome-1 and cysteine 1210 of Period circadian protein homolog 2.
Details
Redox score ?
66
PDB code
4ct0
Structure name
crystal structure of mouse cryptochrome1 in complex with period2
Structure deposition date
2014-03-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
2
% buried
78
Peptide A name
Cryptochrome-1
Peptide B name
Period circadian protein homolog 2
Peptide A accession
P97784
Peptide B accession
O54943
Peptide A residue number
412
Peptide B residue number
1210
Ligandability
Cysteine 412 of Cryptochrome-1
Cysteine 1210 of Period circadian protein homolog 2
4u8h C 430 D 1210
A redox-regulated disulphide may form between cysteine 430 of Cryptochrome-2 and cysteine 1210 of Period circadian protein homolog 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
nan
Peptide A name
Cryptochrome-2
Peptide B name
Period circadian protein homolog 2
Peptide A accession
Q9R194
Peptide B accession
O54943
Peptide A residue number
430
Peptide B residue number
1210
Ligandability
Cysteine 430 of Cryptochrome-2
Cysteine 1210 of Period circadian protein homolog 2
4ct0 A 363 B 1210
A redox-regulated disulphide may form between cysteine 363 of Cryptochrome-1 and cysteine 1210 of Period circadian protein homolog 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4ct0
Structure name
crystal structure of mouse cryptochrome1 in complex with period2
Structure deposition date
2014-03-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
2
% buried
78
Peptide A name
Cryptochrome-1
Peptide B name
Period circadian protein homolog 2
Peptide A accession
P97784
Peptide B accession
O54943
Peptide A residue number
363
Peptide B residue number
1210
Ligandability
Cysteine 363 of Cryptochrome-1
Cysteine 1210 of Period circadian protein homolog 2
4u8h C 430 D 1213
A redox-regulated disulphide may form between cysteine 430 of Cryptochrome-2 and cysteine 1213 of Period circadian protein homolog 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
Cryptochrome-2
Peptide B name
Period circadian protein homolog 2
Peptide A accession
Q9R194
Peptide B accession
O54943
Peptide A residue number
430
Peptide B residue number
1213
Ligandability
Cysteine 430 of Cryptochrome-2
Cysteine 1213 of Period circadian protein homolog 2
4u8h C 381 D 1210
A redox-regulated disulphide may form between cysteine 381 of Cryptochrome-2 and cysteine 1210 of Period circadian protein homolog 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
nan
Peptide A name
Cryptochrome-2
Peptide B name
Period circadian protein homolog 2
Peptide A accession
Q9R194
Peptide B accession
O54943
Peptide A residue number
381
Peptide B residue number
1210
Ligandability
Cysteine 381 of Cryptochrome-2
Cysteine 1210 of Period circadian protein homolog 2
4u8h B 1210 B 1213
A redox-regulated disulphide may form within Period circadian protein homolog 2 between cysteines 1210 and 1213.
Details
Redox score ?
77
PDB code
4u8h
Structure name
crystal structure of mammalian period-cryptochrome complex
Structure deposition date
2014-08-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
1
% buried
52
Peptide accession
O54943
Residue number A
1210
Residue number B
1213
Peptide name
Period circadian protein homolog 2
Ligandability
Cysteine 1210 of Period circadian protein homolog 2
Cysteine 1213 of Period circadian protein homolog 2
3gdi B 307 B 308
A redox-regulated disulphide may form within Period circadian protein homolog 2 between cysteines 307 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3gdi
Structure name
mammalian clock protein mper2 - crystal structure of a pas domain fragment
Structure deposition date
2009-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
40
Peptide accession
O54943
Residue number A
307
Residue number B
308
Peptide name
Period circadian protein homolog 2
Ligandability
Cysteine 307 of Period circadian protein homolog 2
Cysteine 308 of Period circadian protein homolog 2
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