ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guanine nucleotide exchange factor DBS

Intermolecular
Cysteine 952 and cysteine 952 L
Intramolecular
Cysteine 704 and cysteine 714
Cysteine 704 and cysteine 707
Cysteine 742 and cysteine 745
Cysteine 707 and cysteine 789
Cysteine 745 and cysteine 751
Cysteine 707 and cysteine 714
A redox-regulated disulphide may form between two units of Guanine nucleotide exchange factor DBS at cysteines 952 and 952.

Details

Redox score ?
63
PDB code
1lb1
Structure name
crystal structure of the dbl and pleckstrin homology domains of dbs in complex with rhoa
Structure deposition date
2002-04-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
16
Peptide A name
Guanine nucleotide exchange factor DBS
Peptide B name
Guanine nucleotide exchange factor DBS
Peptide A accession
Q64096
Peptide B accession
Q64096
Peptide A residue number
952
Peptide B residue number
952

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 704 and 714.

Details

Redox score ?
76
PDB code
1rj2
Structure name
crystal structure of the dh/ph fragment of dbs without bound gtpase
Structure deposition date
2003-11-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
85
Peptide accession
Q63406
Residue number A
704
Residue number B
714
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 704 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 714 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 704 and 707.

Details

Redox score ?
76
PDB code
1rj2
Structure name
crystal structure of the dh/ph fragment of dbs without bound gtpase
Structure deposition date
2003-11-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
40
Peptide accession
Q63406
Residue number A
704
Residue number B
707
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 704 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 707 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 742 and 745.

Details

Redox score ?
61
PDB code
1rj2
Structure name
crystal structure of the dh/ph fragment of dbs without bound gtpase
Structure deposition date
2003-11-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
54
Peptide accession
Q63406
Residue number A
742
Residue number B
745
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 742 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 745 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 707 and 789. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1kzg
Structure name
dbscdc42(y889f)
Structure deposition date
2002-02-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
58
Peptide accession
Q64096
Residue number A
707
Residue number B
789
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 707 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 789 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 745 and 751. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1kzg
Structure name
dbscdc42(y889f)
Structure deposition date
2002-02-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
39
Peptide accession
Q64096
Residue number A
745
Residue number B
751
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 745 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 751 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor DBS between cysteines 707 and 714. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1rj2
Structure name
crystal structure of the dh/ph fragment of dbs without bound gtpase
Structure deposition date
2003-11-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
59
Peptide accession
Q63406
Residue number A
707
Residue number B
714
Peptide name
Guanine nucleotide exchange factor DBS

Ligandability

Cysteine 707 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 714 of Guanine nucleotide exchange factor DBS

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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