a tool for identifying drug-targetable redox-active disulphides

Serine/threonine-protein kinase DCLK1

Intermolecular

Cysteine 426 and cysteine 548

A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase DCLK1 at cysteines 426 and 548.

Details

Redox score ?

67

PDB code

Structure name

crystal structure of dclk1-cter in complex with fmf-03-055-1

Structure deposition date

2020-12-03

Thiol separation (Å)

5

Half-sphere exposure sum ?

58

Minimum pK_a ?

9

% buried

46

Peptide A name

Serine/threonine-protein kinase DCLK1

Peptide B name

Serine/threonine-protein kinase DCLK1

Peptide A accession

Peptide B accession

Peptide A residue number

426

Peptide B residue number

548

Ligandability

Cysteine 426 of Serine/threonine-protein kinase DCLK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of Serine/threonine-protein kinase DCLK1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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