ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mitochondrial ribonuclease P catalytic subunit

Intramolecular
Cysteine 348 and cysteine 351 L
Cysteine 348 and cysteine 578 L
Cysteine 351 and cysteine 578 L
Cysteine 568 and cysteine 570 L
A redox-regulated disulphide may form within Mitochondrial ribonuclease P catalytic subunit between cysteines 348 and 351.

Details

Redox score ?
82
PDB code
4rou
Structure name
auto-inhibition mechanism of human mitochondrial rnase p protein complex
Structure deposition date
2014-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
30
Peptide accession
O15091
Residue number A
348
Residue number B
351
Peptide name
Mitochondrial ribonuclease P catalytic subunit

Ligandability

Cysteine 348 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial ribonuclease P catalytic subunit between cysteines 348 and 578.

Details

Redox score ?
79
PDB code
4rou
Structure name
auto-inhibition mechanism of human mitochondrial rnase p protein complex
Structure deposition date
2014-10-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
36
Peptide accession
O15091
Residue number A
348
Residue number B
578
Peptide name
Mitochondrial ribonuclease P catalytic subunit

Ligandability

Cysteine 348 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial ribonuclease P catalytic subunit between cysteines 351 and 578.

Details

Redox score ?
75
PDB code
4rou
Structure name
auto-inhibition mechanism of human mitochondrial rnase p protein complex
Structure deposition date
2014-10-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
30
Peptide accession
O15091
Residue number A
351
Residue number B
578
Peptide name
Mitochondrial ribonuclease P catalytic subunit

Ligandability

Cysteine 351 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 578 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mitochondrial ribonuclease P catalytic subunit between cysteines 568 and 570. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
4xgl
Structure name
structure of the nuclease subunit of human mitochondrial rnase p (mrpp3) at 1
Structure deposition date
2014-12-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
22
Peptide accession
O15091
Residue number A
568
Residue number B
570
Peptide name
Mitochondrial ribonuclease P catalytic subunit

Ligandability

Cysteine 568 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 570 of Mitochondrial ribonuclease P catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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