NPC intracellular cholesterol transporter 1
Intramolecular
Cysteine 240 and cysteine 247
Cysteine 177 and cysteine 184
Cysteine 967 and cysteine 976
Cysteine 227 and cysteine 243
Cysteine 909 and cysteine 914
Cysteine 63 and cysteine 109
Cysteine 956 and cysteine 1011
Cysteine 97 and cysteine 238
Cysteine 25 and cysteine 74
Cysteine 516 and cysteine 533
More...Cysteine 957 and cysteine 979
Cysteine 31 and cysteine 42
Cysteine 468 and cysteine 479
Cysteine 75 and cysteine 113
Cysteine 100 and cysteine 160
Cysteine 799 and cysteine 800 L
Cysteine 364 and cysteine 670
Cysteine 227 and cysteine 238
Cysteine 97 and cysteine 227
Cysteine 63 and cysteine 113
Cysteine 238 and cysteine 243
Cysteine 97 and cysteine 100
Cysteine 97 and cysteine 243
Cysteine 243 and cysteine 247
Cysteine 109 and cysteine 113
Cysteine 97 and cysteine 160
Cysteine 63 and cysteine 75
Cysteine 100 and cysteine 238
Cysteine 227 and cysteine 247
Cysteine 240 and cysteine 243
Cysteine 334 and cysteine 1119
Cysteine 976 and cysteine 979
Cysteine 160 and cysteine 238
Cysteine 100 and cysteine 227
Cysteine 238 and cysteine 240
Cysteine 75 and cysteine 109
Cysteine 160 and cysteine 227
Cysteine 967 and cysteine 979
Cysteine 74 and cysteine 75
Cysteine 957 and cysteine 967
3gkh A 240 A 247
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 240 and 247.
Details
Redox score ?
89
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
240
Residue number B
247
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 240 of NPC intracellular cholesterol transporter 1
Cysteine 247 of NPC intracellular cholesterol transporter 1
3gkh A 177 A 184
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 177 and 184.
Details
Redox score ?
87
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
177
Residue number B
184
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 177 of NPC intracellular cholesterol transporter 1
Cysteine 184 of NPC intracellular cholesterol transporter 1
5u74 A 967 A 976
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 967 and 976.
Details
Redox score ?
87
PDB code
5u74
Structure name
structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
967
Residue number B
976
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 967 of NPC intracellular cholesterol transporter 1
Cysteine 976 of NPC intracellular cholesterol transporter 1
3gki A 227 A 243
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 227 and 243.
Details
Redox score ?
86
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
227
Residue number B
243
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 227 of NPC intracellular cholesterol transporter 1
Cysteine 243 of NPC intracellular cholesterol transporter 1
5u74 A 909 A 914
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 909 and 914.
Details
Redox score ?
86
PDB code
5u74
Structure name
structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
909
Residue number B
914
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 909 of NPC intracellular cholesterol transporter 1
Cysteine 914 of NPC intracellular cholesterol transporter 1
3gkh A 63 A 109
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 63 and 109.
Details
Redox score ?
84
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
63
Residue number B
109
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 63 of NPC intracellular cholesterol transporter 1
Cysteine 109 of NPC intracellular cholesterol transporter 1
5u73 A 956 A 1011
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 956 and 1011.
Details
Redox score ?
84
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
956
Residue number B
1011
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 956 of NPC intracellular cholesterol transporter 1
Cysteine 1011 of NPC intracellular cholesterol transporter 1
3gkj A 97 A 238
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 97 and 238.
Details
Redox score ?
84
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
97
Residue number B
238
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 97 of NPC intracellular cholesterol transporter 1
Cysteine 238 of NPC intracellular cholesterol transporter 1
3gkh A 25 A 74
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 25 and 74.
Details
Redox score ?
82
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
25
Residue number B
74
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 25 of NPC intracellular cholesterol transporter 1
Cysteine 74 of NPC intracellular cholesterol transporter 1
5u73 A 516 A 533
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 516 and 533.
Details
Redox score ?
82
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
516
Residue number B
533
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 516 of NPC intracellular cholesterol transporter 1
Cysteine 533 of NPC intracellular cholesterol transporter 1
5u73 A 957 A 979
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 957 and 979.
Details
Redox score ?
82
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
957
Residue number B
979
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 957 of NPC intracellular cholesterol transporter 1
Cysteine 979 of NPC intracellular cholesterol transporter 1
3gkh A 31 A 42
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 31 and 42.
Details
Redox score ?
82
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
31
Residue number B
42
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 31 of NPC intracellular cholesterol transporter 1
Cysteine 42 of NPC intracellular cholesterol transporter 1
5u73 A 468 A 479
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 468 and 479.
Details
Redox score ?
80
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
468
Residue number B
479
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 468 of NPC intracellular cholesterol transporter 1
Cysteine 479 of NPC intracellular cholesterol transporter 1
3gkj A 75 A 113
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 75 and 113.
Details
Redox score ?
80
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
75
Residue number B
113
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 75 of NPC intracellular cholesterol transporter 1
Cysteine 113 of NPC intracellular cholesterol transporter 1
3gkj A 100 A 160
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 100 and 160.
Details
Redox score ?
78
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
100
Residue number B
160
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 100 of NPC intracellular cholesterol transporter 1
Cysteine 160 of NPC intracellular cholesterol transporter 1
6w5r A 799 A 800
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 799 and 800.
Details
Redox score ?
77
PDB code
6w5r
Structure name
npc1 structure in nanodisc
Structure deposition date
2020-03-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
25
Minimum pKa ?
9
% buried
0
Peptide accession
O15118
Residue number A
799
Residue number B
800
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 799 of NPC intracellular cholesterol transporter 1
Cysteine 800 of NPC intracellular cholesterol transporter 1
5u73 A 364 A 670
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 364 and 670.
Details
Redox score ?
67
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
42
Peptide accession
O15118
Residue number A
364
Residue number B
670
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 364 of NPC intracellular cholesterol transporter 1
Cysteine 670 of NPC intracellular cholesterol transporter 1
3gki A 227 A 238
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 227 and 238.
Details
Redox score ?
67
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
227
Residue number B
238
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 227 of NPC intracellular cholesterol transporter 1
Cysteine 238 of NPC intracellular cholesterol transporter 1
3gki A 97 A 227
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 97 and 227.
Details
Redox score ?
66
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
97
Residue number B
227
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 97 of NPC intracellular cholesterol transporter 1
Cysteine 227 of NPC intracellular cholesterol transporter 1
3gki A 63 A 113
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 63 and 113.
Details
Redox score ?
66
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
63
Residue number B
113
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 63 of NPC intracellular cholesterol transporter 1
Cysteine 113 of NPC intracellular cholesterol transporter 1
3gkh A 238 A 243
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 238 and 243.
Details
Redox score ?
66
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
238
Residue number B
243
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 238 of NPC intracellular cholesterol transporter 1
Cysteine 243 of NPC intracellular cholesterol transporter 1
3gki A 97 A 100
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 97 and 100.
Details
Redox score ?
63
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
97
Residue number B
100
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 97 of NPC intracellular cholesterol transporter 1
Cysteine 100 of NPC intracellular cholesterol transporter 1
3gkj A 97 A 243
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 97 and 243.
Details
Redox score ?
62
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
97
Residue number B
243
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 97 of NPC intracellular cholesterol transporter 1
Cysteine 243 of NPC intracellular cholesterol transporter 1
3gkh A 243 A 247
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 243 and 247.
Details
Redox score ?
60
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
243
Residue number B
247
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 243 of NPC intracellular cholesterol transporter 1
Cysteine 247 of NPC intracellular cholesterol transporter 1
3gkj A 109 A 113
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 109 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
109
Residue number B
113
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 109 of NPC intracellular cholesterol transporter 1
Cysteine 113 of NPC intracellular cholesterol transporter 1
3gkj A 97 A 160
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 97 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
97
Residue number B
160
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 97 of NPC intracellular cholesterol transporter 1
Cysteine 160 of NPC intracellular cholesterol transporter 1
3gkj A 63 A 75
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 63 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
63
Residue number B
75
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 63 of NPC intracellular cholesterol transporter 1
Cysteine 75 of NPC intracellular cholesterol transporter 1
3gki A 100 A 238
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 100 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
100
Residue number B
238
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 100 of NPC intracellular cholesterol transporter 1
Cysteine 238 of NPC intracellular cholesterol transporter 1
3gki A 227 A 247
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 227 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
227
Residue number B
247
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 227 of NPC intracellular cholesterol transporter 1
Cysteine 247 of NPC intracellular cholesterol transporter 1
3gkh A 240 A 243
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 240 and 243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
240
Residue number B
243
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 240 of NPC intracellular cholesterol transporter 1
Cysteine 243 of NPC intracellular cholesterol transporter 1
6uox A 334 A 1119
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 334 and 1119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6uox
Structure name
structure of itraconazole-bound npc1
Structure deposition date
2019-10-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
O15118
Residue number A
334
Residue number B
1119
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 334 of NPC intracellular cholesterol transporter 1
Cysteine 1119 of NPC intracellular cholesterol transporter 1
5u73 A 976 A 979
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 976 and 979. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
976
Residue number B
979
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 976 of NPC intracellular cholesterol transporter 1
Cysteine 979 of NPC intracellular cholesterol transporter 1
3gki A 160 A 238
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 160 and 238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
160
Residue number B
238
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 160 of NPC intracellular cholesterol transporter 1
Cysteine 238 of NPC intracellular cholesterol transporter 1
3gkj A 100 A 227
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 100 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3gkj
Structure name
npc1d(ntd):25hydroxycholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
100
Residue number B
227
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 100 of NPC intracellular cholesterol transporter 1
Cysteine 227 of NPC intracellular cholesterol transporter 1
6w5u A 238 A 240
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 238 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6w5u
Structure name
npc1 structure in gdn micelles at ph 5
Structure deposition date
2020-03-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
238
Residue number B
240
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 238 of NPC intracellular cholesterol transporter 1
Cysteine 240 of NPC intracellular cholesterol transporter 1
3gki A 75 A 109
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 75 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3gki
Structure name
npc1(ntd):cholesterol
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
75
Residue number B
109
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 75 of NPC intracellular cholesterol transporter 1
Cysteine 109 of NPC intracellular cholesterol transporter 1
3gkh A 160 A 227
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 160 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
160
Residue number B
227
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 160 of NPC intracellular cholesterol transporter 1
Cysteine 227 of NPC intracellular cholesterol transporter 1
5u74 A 967 A 979
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 967 and 979. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5u74
Structure name
structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
967
Residue number B
979
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 967 of NPC intracellular cholesterol transporter 1
Cysteine 979 of NPC intracellular cholesterol transporter 1
3gkh A 74 A 75
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 74 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3gkh
Structure name
npc1(ntd)
Structure deposition date
2009-03-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
74
Residue number B
75
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 74 of NPC intracellular cholesterol transporter 1
Cysteine 75 of NPC intracellular cholesterol transporter 1
5u73 A 957 A 967
A redox-regulated disulphide may form within NPC intracellular cholesterol transporter 1 between cysteines 957 and 967. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5u73
Structure name
crystal structure of human niemann-pick c1 protein
Structure deposition date
2016-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15118
Residue number A
957
Residue number B
967
Peptide name
NPC intracellular cholesterol transporter 1
Ligandability
Cysteine 957 of NPC intracellular cholesterol transporter 1
Cysteine 967 of NPC intracellular cholesterol transporter 1
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