ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Angiopoietin-2

Intramolecular
Cysteine 433 and cysteine 435
Cysteine 284 and cysteine 313
Cysteine 437 and cysteine 450
Cysteine 435 and cysteine 437
Cysteine 433 and cysteine 437
Cysteine 433 and cysteine 450
Cysteine 435 and cysteine 450
A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 433 and 435.

Details

Redox score ?
85
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
433
Residue number B
435
Peptide name
Angiopoietin-2

Ligandability

Cysteine 433 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 435 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 284 and 313.

Details

Redox score ?
82
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
284
Residue number B
313
Peptide name
Angiopoietin-2

Ligandability

Cysteine 284 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 437 and 450.

Details

Redox score ?
78
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
437
Residue number B
450
Peptide name
Angiopoietin-2

Ligandability

Cysteine 437 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 435 and 437 (157 and 159 respectively in this structure).

Details

Redox score ?
73
PDB code
4jzc
Structure name
angiopoietin-2 fibrinogen domain tag mutant
Structure deposition date
2013-04-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
435
Residue number B
437
Peptide name
Angiopoietin-2

Ligandability

Cysteine 435 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 433 and 437.

Details

Redox score ?
71
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
433
Residue number B
437
Peptide name
Angiopoietin-2

Ligandability

Cysteine 433 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 437 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 433 and 450.

Details

Redox score ?
69
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
433
Residue number B
450
Peptide name
Angiopoietin-2

Ligandability

Cysteine 433 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiopoietin-2 between cysteines 435 and 450.

Details

Redox score ?
65
PDB code
2gy7
Structure name
angiopoietin-2/tie2 complex crystal structure
Structure deposition date
2006-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15123
Residue number A
435
Residue number B
450
Peptide name
Angiopoietin-2

Ligandability

Cysteine 435 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Angiopoietin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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