ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Importin subunit alpha-6

Intramolecular
Cysteine 338 and cysteine 343
Cysteine 425 and cysteine 430
A redox-regulated disulphide may form within Importin subunit alpha-6 between cysteines 338 and 343.

Details

Redox score ?
80
PDB code
4u2x
Structure name
ebola virus vp24 in complex with karyopherin alpha 5 c-terminus
Structure deposition date
2014-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
9
% buried
0
Peptide accession
O15131
Residue number A
338
Residue number B
343
Peptide name
Importin subunit alpha-6

Ligandability

Cysteine 338 of Importin subunit alpha-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 343 of Importin subunit alpha-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin subunit alpha-6 between cysteines 425 and 430. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4u2x
Structure name
ebola virus vp24 in complex with karyopherin alpha 5 c-terminus
Structure deposition date
2014-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
98
Peptide accession
O15131
Residue number A
425
Residue number B
430
Peptide name
Importin subunit alpha-6

Ligandability

Cysteine 425 of Importin subunit alpha-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 430 of Importin subunit alpha-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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