ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Muscle, skeletal receptor tyrosine protein kinase

Intramolecular
Cysteine 317 and cysteine 382
Cysteine 398 and cysteine 434
Cysteine 325 and cysteine 375
Cysteine 142 and cysteine 190
Cysteine 366 and cysteine 406
Cysteine 394 and cysteine 447
Cysteine 49 and cysteine 99
Cysteine 98 and cysteine 112
Cysteine 822 and cysteine 826
Cysteine 644 and cysteine 651
More...
Cysteine 703 and cysteine 859
Cysteine 698 and cysteine 826
Cysteine 99 and cysteine 112
Cysteine 698 and cysteine 859
Cysteine 98 and cysteine 99
Cysteine 49 and cysteine 112
Cysteine 49 and cysteine 98
A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 317 and 382.

Details

Redox score ?
84
PDB code
3hkl
Structure name
crystal structure of the frizzled-like cysteine-rich domain of musk
Structure deposition date
2009-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
317
Residue number B
382
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 317 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 382 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 398 and 434.

Details

Redox score ?
84
PDB code
3hkl
Structure name
crystal structure of the frizzled-like cysteine-rich domain of musk
Structure deposition date
2009-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
398
Residue number B
434
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 398 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 434 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 325 and 375.

Details

Redox score ?
82
PDB code
3hkl
Structure name
crystal structure of the frizzled-like cysteine-rich domain of musk
Structure deposition date
2009-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
325
Residue number B
375
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 325 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 375 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 142 and 190.

Details

Redox score ?
82
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
142
Residue number B
190
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 142 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 190 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 366 and 406.

Details

Redox score ?
81
PDB code
3hkl
Structure name
crystal structure of the frizzled-like cysteine-rich domain of musk
Structure deposition date
2009-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
366
Residue number B
406
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 366 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 406 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 394 and 447.

Details

Redox score ?
80
PDB code
3hkl
Structure name
crystal structure of the frizzled-like cysteine-rich domain of musk
Structure deposition date
2009-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
394
Residue number B
447
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 394 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 447 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 49 and 99.

Details

Redox score ?
79
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
49
Residue number B
99
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 49 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 99 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 98 and 112.

Details

Redox score ?
79
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
98
Residue number B
112
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 98 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 112 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 822 and 826.

Details

Redox score ?
74
PDB code
1luf
Structure name
crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
Structure deposition date
2002-05-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
31
Peptide accession
Q62838
Residue number A
822
Residue number B
826
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 822 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 826 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 644 and 651.

Details

Redox score ?
69
PDB code
1luf
Structure name
crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
Structure deposition date
2002-05-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
65
Peptide accession
Q62838
Residue number A
644
Residue number B
651
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 644 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 651 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 703 and 859. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1luf
Structure name
crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
Structure deposition date
2002-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
29
Peptide accession
Q62838
Residue number A
703
Residue number B
859
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 703 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 859 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 698 and 826. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1luf
Structure name
crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
Structure deposition date
2002-05-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
36
Peptide accession
Q62838
Residue number A
698
Residue number B
826
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 698 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 826 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 99 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
99
Residue number B
112
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 99 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 112 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 698 and 859. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1luf
Structure name
crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
Structure deposition date
2002-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
10
% buried
22
Peptide accession
Q62838
Residue number A
698
Residue number B
859
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 698 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 859 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 98 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
98
Residue number B
99
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 98 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 99 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 49 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
49
Residue number B
112
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 49 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 112 of Muscle, skeletal receptor tyrosine protein kinase

A redox-regulated disulphide may form within Muscle, skeletal receptor tyrosine protein kinase between cysteines 49 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2iep
Structure name
crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
Structure deposition date
2006-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62838
Residue number A
49
Residue number B
98
Peptide name
Muscle, skeletal receptor tyrosine protein kinase

Ligandability

Cysteine 49 of Muscle, skeletal receptor tyrosine protein kinase

Cysteine 98 of Muscle, skeletal receptor tyrosine protein kinase

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