a tool for identifying drug-targetable redox-active disulphides

DNA-directed RNA polymerases I and III subunit RPAC1

Intermolecular

Cysteine 333 and cysteine 107 of DNA-directed RNA polymerases I and III subunit RPAC2

A redox-regulated disulphide may form between cysteine 333 of DNA-directed RNA polymerases I and III subunit RPAC1 and cysteine 107 of DNA-directed RNA polymerases I and III subunit RPAC2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

54

PDB code

Structure name

cryo-em structure of human apo rna polymerase iii

Structure deposition date

2020-08-25

Thiol separation (Å)

5

Half-sphere exposure sum ?

71

Minimum pK_a ?

12

% buried

98

Peptide A name

DNA-directed RNA polymerases I and III subunit RPAC1

Peptide B name

DNA-directed RNA polymerases I and III subunit RPAC2

Peptide A accession

Peptide B accession

Peptide A residue number

333

Peptide B residue number

107

Ligandability

Cysteine 333 of DNA-directed RNA polymerases I and III subunit RPAC1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of DNA-directed RNA polymerases I and III subunit RPAC2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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