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Transcription intermediary factor 1-alpha

Intermolecular
Cysteine 917 and cysteine 917
Intramolecular
Cysteine 829 and cysteine 832
Cysteine 829 and cysteine 852
Cysteine 841 and cysteine 870
Cysteine 841 and cysteine 844
Cysteine 841 and cysteine 867
Cysteine 844 and cysteine 870
Cysteine 844 and cysteine 867
Cysteine 832 and cysteine 852
Cysteine 867 and cysteine 870
More...
Cysteine 829 and cysteine 917
Cysteine 840 and cysteine 844
Cysteine 844 and cysteine 917
Cysteine 840 and cysteine 841
Cysteine 867 and cysteine 917
Cysteine 852 and cysteine 917
Cysteine 832 and cysteine 917
A redox-regulated disulphide may form between two units of Transcription intermediary factor 1-alpha at cysteines 917 and 917 (34 and 34 respectively in this structure).

Details

Redox score ?
83
PDB code
2yyn
Structure name
crystal structure of human bromodomain protein
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Transcription intermediary factor 1-alpha
Peptide B name
Transcription intermediary factor 1-alpha
Peptide A accession
O15164
Peptide B accession
O15164
Peptide A residue number
917
Peptide B residue number
917

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 829 and 832.

Details

Redox score ?
87
PDB code
3o35
Structure name
crystal structure of trim24 phd-bromo complexed with h3(23-31)k27ac peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
3
% buried
30
Peptide accession
O15164
Residue number A
829
Residue number B
832
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 829 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 832 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 829 and 852.

Details

Redox score ?
84
PDB code
3o37
Structure name
crystal structure of trim24 phd-bromo complexed with h3(1-10)k4 peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
3
% buried
69
Peptide accession
O15164
Residue number A
829
Residue number B
852
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 829 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 852 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 841 and 870.

Details

Redox score ?
84
PDB code
3o33
Structure name
crystal structure of trim24 phd-bromo in the free state
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
30
Peptide accession
O15164
Residue number A
841
Residue number B
870
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 841 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 870 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 841 and 844.

Details

Redox score ?
83
PDB code
5h1v
Structure name
complex structure of trim24 phd-bromodomain and inhibitor 6
Structure deposition date
2016-10-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
32
Peptide accession
O15164
Residue number A
841
Residue number B
844
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 841 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 844 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 841 and 867.

Details

Redox score ?
80
PDB code
3o33
Structure name
crystal structure of trim24 phd-bromo in the free state
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
55
Peptide accession
O15164
Residue number A
841
Residue number B
867
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 841 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 867 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 844 and 870.

Details

Redox score ?
79
PDB code
5h1t
Structure name
complex structure of trim24 phd-bromodomain and inhibitor 1
Structure deposition date
2016-10-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
26
Peptide accession
O15164
Residue number A
844
Residue number B
870
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 844 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 870 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 844 and 867.

Details

Redox score ?
73
PDB code
3o33
Structure name
crystal structure of trim24 phd-bromo in the free state
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
49
Peptide accession
O15164
Residue number A
844
Residue number B
867
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 844 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 867 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 832 and 852.

Details

Redox score ?
71
PDB code
5h1t
Structure name
complex structure of trim24 phd-bromodomain and inhibitor 1
Structure deposition date
2016-10-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
34
Peptide accession
O15164
Residue number A
832
Residue number B
852
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 832 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 852 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 867 and 870.

Details

Redox score ?
70
PDB code
3o34
Structure name
crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
42
Peptide accession
O15164
Residue number A
867
Residue number B
870
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 867 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 870 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 829 and 917.

Details

Redox score ?
67
PDB code
3o34
Structure name
crystal structure of trim24 phd-bromo complexed with h3(13-32)k23ac peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
2
% buried
61
Peptide accession
O15164
Residue number A
829
Residue number B
917
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 829 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 917 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 840 and 844. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5h1t
Structure name
complex structure of trim24 phd-bromodomain and inhibitor 1
Structure deposition date
2016-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
18
Peptide accession
O15164
Residue number A
840
Residue number B
844
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 840 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 844 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 844 and 917. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5h1u
Structure name
complex structure of trim24 phd-bromodomain and inhibitor 2
Structure deposition date
2016-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
54
Peptide accession
O15164
Residue number A
844
Residue number B
917
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 844 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 917 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 840 and 841. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3o37
Structure name
crystal structure of trim24 phd-bromo complexed with h3(1-10)k4 peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
nan
Peptide accession
O15164
Residue number A
840
Residue number B
841
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 840 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 841 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 867 and 917. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3o36
Structure name
crystal structure of trim24 phd-bromo complexed with h4(14-19)k16ac peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
76
Peptide accession
O15164
Residue number A
867
Residue number B
917
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 867 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 917 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 852 and 917. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3o35
Structure name
crystal structure of trim24 phd-bromo complexed with h3(23-31)k27ac peptide
Structure deposition date
2010-07-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
62
Peptide accession
O15164
Residue number A
852
Residue number B
917
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 852 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 917 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription intermediary factor 1-alpha between cysteines 832 and 917. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3o33
Structure name
crystal structure of trim24 phd-bromo in the free state
Structure deposition date
2010-07-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
64
Peptide accession
O15164
Residue number A
832
Residue number B
917
Peptide name
Transcription intermediary factor 1-alpha

Ligandability

Cysteine 832 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 917 of Transcription intermediary factor 1-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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