a tool for identifying drug-targetable redox-active disulphides

Axin-1

Intermolecular

Cysteine 121 and cysteine 2042 of Adenomatous polyposis coli protein

A redox-regulated disulphide may form between cysteine 121 of Axin-1 and cysteine 2042 of Adenomatous polyposis coli protein (158 and 2043 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

structure of the axin rgs-homologous domain in complex with a samp repeat from apc

Structure deposition date

2000-03-17

Thiol separation (Å)

8

Half-sphere exposure sum ?

74

Minimum pK_a ?

12

% buried

86

Peptide A name

Axin-1

Peptide B name

Adenomatous polyposis coli protein

Peptide A accession

Peptide B accession

Peptide A residue number

121

Peptide B residue number

2042

Ligandability

Cysteine 121 of Axin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2042 of Adenomatous polyposis coli protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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