ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ral guanine nucleotide dissociation stimulator-like 2

Intramolecular
Cysteine 267 and cysteine 284
A redox-regulated disulphide may form within Ral guanine nucleotide dissociation stimulator-like 2 between cysteines 267 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
4jgw
Structure name
the conformation of a docking site for sh3 domains is pre-selected in the guanine nucleotide exchange factor rlf
Structure deposition date
2013-03-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
50
Peptide accession
Q61193
Residue number A
267
Residue number B
284
Peptide name
Ral guanine nucleotide dissociation stimulator-like 2

Ligandability

Cysteine 267 of Ral guanine nucleotide dissociation stimulator-like 2

Cysteine 284 of Ral guanine nucleotide dissociation stimulator-like 2

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