Ataxin-7
Intermolecular
Cysteine 41 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L and cysteine 509
Intramolecular
Cysteine 358 and cysteine 364
Cysteine 347 and cysteine 364
Cysteine 347 and cysteine 358
8h7g K 41 L 509
A redox-regulated disulphide may form between cysteine 41 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L and cysteine 509 of Ataxin-7.
Details
Redox score ?
64
PDB code
8h7g
Structure name
cryo-em structure of the human saga complex
Structure deposition date
2022-10-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Peptide B name
Ataxin-7
Peptide A accession
Q9Y6J9
Peptide B accession
O15265
Peptide A residue number
41
Peptide B residue number
509
Ligandability
Cysteine 41 of TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Cysteine 509 of Ataxin-7
2kkr A 358 A 364
A redox-regulated disulphide may form within Ataxin-7 between cysteines 358 and 364.
Details
Redox score ?
86
PDB code
2kkr
Structure name
solution structure of sca7 zinc finger domain from human ataxin-7 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
28
Peptide accession
O15265
Residue number A
358
Residue number B
364
Peptide name
Ataxin-7
Ligandability
Cysteine 358 of Ataxin-7
Cysteine 364 of Ataxin-7
2kkr A 347 A 364
A redox-regulated disulphide may form within Ataxin-7 between cysteines 347 and 364.
Details
Redox score ?
84
PDB code
2kkr
Structure name
solution structure of sca7 zinc finger domain from human ataxin-7 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
6
% buried
38
Peptide accession
O15265
Residue number A
347
Residue number B
364
Peptide name
Ataxin-7
Ligandability
Cysteine 347 of Ataxin-7
Cysteine 364 of Ataxin-7
2kkr A 347 A 358
A redox-regulated disulphide may form within Ataxin-7 between cysteines 347 and 358.
Details
Redox score ?
74
PDB code
2kkr
Structure name
solution structure of sca7 zinc finger domain from human ataxin-7 protein
Structure deposition date
2009-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
34
Peptide accession
O15265
Residue number A
347
Residue number B
358
Peptide name
Ataxin-7
Ligandability
Cysteine 347 of Ataxin-7
Cysteine 358 of Ataxin-7
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