ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine palmitoyltransferase 2

Intermolecular
Cysteine 133 of Serine palmitoyltransferase 1 and cysteine 511 L
Intramolecular
Cysteine 188 and cysteine 425
Cysteine 425 and cysteine 438
Cysteine 188 and cysteine 438
A redox-regulated disulphide may form between cysteine 133 of Serine palmitoyltransferase 1 and cysteine 511 of Serine palmitoyltransferase 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6m4n
Structure name
cryo-em structure of the dimeric spt-ormdl3 complex
Structure deposition date
2020-03-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
98
Minimum pKa ?
10
% buried
100
Peptide A name
Serine palmitoyltransferase 1
Peptide B name
Serine palmitoyltransferase 2
Peptide A accession
O15269
Peptide B accession
O15270
Peptide A residue number
133
Peptide B residue number
511

Ligandability

Cysteine 133 of Serine palmitoyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 511 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine palmitoyltransferase 2 between cysteines 188 and 425.

Details

Redox score ?
68
PDB code
6m4o
Structure name
cryo-em structure of the monomeric spt-ormdl3 complex
Structure deposition date
2020-03-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
47
Peptide accession
O15270
Residue number A
188
Residue number B
425
Peptide name
Serine palmitoyltransferase 2

Ligandability

Cysteine 188 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 425 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine palmitoyltransferase 2 between cysteines 425 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7k0l
Structure name
human serine palmitoyltransferase complex sptlc1/spltc2/ssspta, myriocin-bound
Structure deposition date
2020-09-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
47
Peptide accession
O15270
Residue number A
425
Residue number B
438
Peptide name
Serine palmitoyltransferase 2

Ligandability

Cysteine 425 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 438 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine palmitoyltransferase 2 between cysteines 188 and 438. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7k0q
Structure name
human serine palmitoyltransferase complex sptlc1/spltc2/ssspta/ormdl3, myriocin-bound
Structure deposition date
2020-09-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
62
Peptide accession
O15270
Residue number A
188
Residue number B
438
Peptide name
Serine palmitoyltransferase 2

Ligandability

Cysteine 188 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 438 of Serine palmitoyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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