ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Polyunsaturated fatty acid lipoxygenase ALOX15B

Intramolecular
Cysteine 89 and cysteine 106
A redox-regulated disulphide may form within Polyunsaturated fatty acid lipoxygenase ALOX15B between cysteines 89 and 106.

Details

Redox score ?
69
PDB code
7laf
Structure name
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
Structure deposition date
2021-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
100
Peptide accession
O15296
Residue number A
89
Residue number B
106
Peptide name
Polyunsaturated fatty acid lipoxygenase ALOX15B

Ligandability

Cysteine 89 of Polyunsaturated fatty acid lipoxygenase ALOX15B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Polyunsaturated fatty acid lipoxygenase ALOX15B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: