ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phosphomannomutase 2

Intramolecular
Cysteine 9 and cysteine 241
Cysteine 83 and cysteine 192
A redox-regulated disulphide may form within Phosphomannomutase 2 between cysteines 9 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7o58
Structure name
human phosphomannomutase 2 (pmm2) with mutation t237m in complex with the activator glucose 1,6-bisphosphate
Structure deposition date
2021-04-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
80
Peptide accession
O15305
Residue number A
9
Residue number B
241
Peptide name
Phosphomannomutase 2

Ligandability

Cysteine 9 of Phosphomannomutase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Phosphomannomutase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphomannomutase 2 between cysteines 83 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2q4r
Structure name
ensemble refinement of the protein crystal structure of human phosphomannomutase 2 (pmm2)
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
66
Peptide accession
O15305
Residue number A
83
Residue number B
192
Peptide name
Phosphomannomutase 2

Ligandability

Cysteine 83 of Phosphomannomutase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Phosphomannomutase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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