ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Baculoviral IAP repeat-containing protein 5

Intramolecular
Cysteine 60 and cysteine 84 L
Cysteine 57 and cysteine 84 L
Cysteine 57 and cysteine 60
Cysteine 31 and cysteine 33
A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 5 between cysteines 60 and 84.

Details

Redox score ?
89
PDB code
6sho
Structure name
sad structure of human survivin recovered by continuous rotation data collection and multivariate analysis of friedel pairs
Structure deposition date
2019-08-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
3
% buried
59
Peptide accession
O15392
Residue number A
60
Residue number B
84
Peptide name
Baculoviral IAP repeat-containing protein 5

Ligandability

Cysteine 60 of Baculoviral IAP repeat-containing protein 5

Cysteine 84 of Baculoviral IAP repeat-containing protein 5

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 5 between cysteines 57 and 84.

Details

Redox score ?
78
PDB code
3uei
Structure name
crystal structure of human survivin e65a mutant
Structure deposition date
2011-10-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
7
% buried
68
Peptide accession
O15392
Residue number A
57
Residue number B
84
Peptide name
Baculoviral IAP repeat-containing protein 5

Ligandability

Cysteine 57 of Baculoviral IAP repeat-containing protein 5

Cysteine 84 of Baculoviral IAP repeat-containing protein 5

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 5 between cysteines 57 and 60.

Details

Redox score ?
78
PDB code
2rax
Structure name
crystal structure of borealin (20-78) bound to survivin (1-120)
Structure deposition date
2007-09-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
7
% buried
nan
Peptide accession
O15392
Residue number A
57
Residue number B
60
Peptide name
Baculoviral IAP repeat-containing protein 5

Ligandability

Cysteine 57 of Baculoviral IAP repeat-containing protein 5

Cysteine 60 of Baculoviral IAP repeat-containing protein 5

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 5 between cysteines 31 and 33.

Details

Redox score ?
77
PDB code
2rax
Structure name
crystal structure of borealin (20-78) bound to survivin (1-120)
Structure deposition date
2007-09-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
15
Peptide accession
O15392
Residue number A
31
Residue number B
33
Peptide name
Baculoviral IAP repeat-containing protein 5

Ligandability

Cysteine 31 of Baculoviral IAP repeat-containing protein 5

Cysteine 33 of Baculoviral IAP repeat-containing protein 5

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