ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neural cell adhesion molecule 2

Intramolecular
Cysteine 136 and cysteine 186
Cysteine 232 and cysteine 281
Cysteine 42 and cysteine 93
Cysteine 422 and cysteine 475
Cysteine 322 and cysteine 380
A redox-regulated disulphide may form within Neural cell adhesion molecule 2 between cysteines 136 and 186.

Details

Redox score ?
83
PDB code
2wim
Structure name
crystal structure of ncam2 ig1-3
Structure deposition date
2009-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15394
Residue number A
136
Residue number B
186
Peptide name
Neural cell adhesion molecule 2

Ligandability

Cysteine 136 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neural cell adhesion molecule 2 between cysteines 232 and 281.

Details

Redox score ?
81
PDB code
2wim
Structure name
crystal structure of ncam2 ig1-3
Structure deposition date
2009-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15394
Residue number A
232
Residue number B
281
Peptide name
Neural cell adhesion molecule 2

Ligandability

Cysteine 232 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neural cell adhesion molecule 2 between cysteines 42 and 93.

Details

Redox score ?
81
PDB code
2wim
Structure name
crystal structure of ncam2 ig1-3
Structure deposition date
2009-05-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15394
Residue number A
42
Residue number B
93
Peptide name
Neural cell adhesion molecule 2

Ligandability

Cysteine 42 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neural cell adhesion molecule 2 between cysteines 422 and 475.

Details

Redox score ?
81
PDB code
2jll
Structure name
crystal structure of ncam2 igiv-fn3ii
Structure deposition date
2008-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15394
Residue number A
422
Residue number B
475
Peptide name
Neural cell adhesion molecule 2

Ligandability

Cysteine 422 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neural cell adhesion molecule 2 between cysteines 322 and 380.

Details

Redox score ?
80
PDB code
2jll
Structure name
crystal structure of ncam2 igiv-fn3ii
Structure deposition date
2008-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15394
Residue number A
322
Residue number B
380
Peptide name
Neural cell adhesion molecule 2

Ligandability

Cysteine 322 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Neural cell adhesion molecule 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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