ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calpain-5

Intramolecular
Cysteine 87 and cysteine 160
Cysteine 87 and cysteine 150
Cysteine 150 and cysteine 160
Cysteine 81 and cysteine 150
A redox-regulated disulphide may form within Calpain-5 between cysteines 87 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6p3q
Structure name
calpain-5 (capn5) protease core (pc)
Structure deposition date
2019-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
97
Minimum pKa ?
10
% buried
100
Peptide accession
O15484
Residue number A
87
Residue number B
160
Peptide name
Calpain-5

Ligandability

Cysteine 87 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calpain-5 between cysteines 87 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6p3q
Structure name
calpain-5 (capn5) protease core (pc)
Structure deposition date
2019-05-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
10
% buried
100
Peptide accession
O15484
Residue number A
87
Residue number B
150
Peptide name
Calpain-5

Ligandability

Cysteine 87 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calpain-5 between cysteines 150 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6p3q
Structure name
calpain-5 (capn5) protease core (pc)
Structure deposition date
2019-05-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
91
Minimum pKa ?
17
% buried
100
Peptide accession
O15484
Residue number A
150
Residue number B
160
Peptide name
Calpain-5

Ligandability

Cysteine 150 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calpain-5 between cysteines 81 and 150. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6p3q
Structure name
calpain-5 (capn5) protease core (pc)
Structure deposition date
2019-05-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
84
Peptide accession
O15484
Residue number A
81
Residue number B
150
Peptide name
Calpain-5

Ligandability

Cysteine 81 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Calpain-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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