Group 10 secretory phospholipase A2
Intermolecular
Cysteine 125 and cysteine 125
Cysteine 100 and cysteine 125
Intramolecular
Cysteine 90 and cysteine 164
Cysteine 53 and cysteine 111
Cysteine 118 and cysteine 130
Cysteine 67 and cysteine 157
Cysteine 69 and cysteine 85
Cysteine 91 and cysteine 132
Cysteine 84 and cysteine 139
Cysteine 84 and cysteine 85
More...Cysteine 69 and cysteine 84
Cysteine 85 and cysteine 139
Cysteine 100 and cysteine 132
Cysteine 90 and cysteine 91
Cysteine 91 and cysteine 164
Cysteine 69 and cysteine 139
Cysteine 91 and cysteine 100
Cysteine 118 and cysteine 132
Cysteine 53 and cysteine 118
Cysteine 130 and cysteine 132
Cysteine 67 and cysteine 69
Cysteine 90 and cysteine 132
5owc A 83 B 83
A redox-regulated disulphide may form between two units of Group 10 secretory phospholipase A2 at cysteines 125 and 125 (83 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
5owc
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Group 10 secretory phospholipase A2
Peptide B name
Group 10 secretory phospholipase A2
Peptide A accession
O15496
Peptide B accession
O15496
Peptide A residue number
125
Peptide B residue number
125
Ligandability
5g3m A 58 B 83
A redox-regulated disulphide may form between two units of Group 10 secretory phospholipase A2 at cysteines 100 and 125 (58 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5g3m
Structure name
discovery of a novel secreted phospholipase a2 (spla2) inhibitor
Structure deposition date
2016-04-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Group 10 secretory phospholipase A2
Peptide B name
Group 10 secretory phospholipase A2
Peptide A accession
O15496
Peptide B accession
O15496
Peptide A residue number
100
Peptide B residue number
125
Ligandability
Cysteine 100 of Group 10 secretory phospholipase A2
Cysteine 125 of Group 10 secretory phospholipase A2
1le6 B 48 B 122
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 90 and 164 (48 and 122 respectively in this structure).
Details
Redox score ?
85
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
90
Residue number B
164
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 90 of Group 10 secretory phospholipase A2
Cysteine 164 of Group 10 secretory phospholipase A2
5owc A 11 A 69
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 53 and 111 (11 and 69 respectively in this structure).
Details
Redox score ?
85
PDB code
5owc
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
53
Residue number B
111
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 53 of Group 10 secretory phospholipase A2
Cysteine 111 of Group 10 secretory phospholipase A2
5ow8 A 76 A 88
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 118 and 130 (76 and 88 respectively in this structure).
Details
Redox score ?
84
PDB code
5ow8
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
118
Residue number B
130
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 118 of Group 10 secretory phospholipase A2
Cysteine 130 of Group 10 secretory phospholipase A2
1le6 A 25 A 115
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 67 and 157 (25 and 115 respectively in this structure).
Details
Redox score ?
83
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
67
Residue number B
157
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 67 of Group 10 secretory phospholipase A2
Cysteine 157 of Group 10 secretory phospholipase A2
5ow8 B 27 B 43
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 69 and 85 (27 and 43 respectively in this structure).
Details
Redox score ?
80
PDB code
5ow8
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
69
Residue number B
85
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 69 of Group 10 secretory phospholipase A2
Cysteine 85 of Group 10 secretory phospholipase A2
6g5j B 49 B 90
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 91 and 132 (49 and 90 respectively in this structure).
Details
Redox score ?
80
PDB code
6g5j
Structure name
secreted phospholipase a2 type x in complex with ligand
Structure deposition date
2018-03-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
91
Residue number B
132
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 91 of Group 10 secretory phospholipase A2
Cysteine 132 of Group 10 secretory phospholipase A2
5ow8 B 42 B 97
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 84 and 139 (42 and 97 respectively in this structure).
Details
Redox score ?
80
PDB code
5ow8
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
84
Residue number B
139
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 84 of Group 10 secretory phospholipase A2
Cysteine 139 of Group 10 secretory phospholipase A2
1le6 C 42 C 43
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 84 and 85 (42 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
84
Residue number B
85
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 84 of Group 10 secretory phospholipase A2
Cysteine 85 of Group 10 secretory phospholipase A2
5owc A 27 A 42
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 69 and 84 (27 and 42 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
5owc
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
69
Residue number B
84
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 69 of Group 10 secretory phospholipase A2
Cysteine 84 of Group 10 secretory phospholipase A2
4uy1 B 43 B 97
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 85 and 139 (43 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4uy1
Structure name
novel pyrazole series of group x secretory phospholipase a2 (spla2-x) inhibitors
Structure deposition date
2014-08-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
85
Residue number B
139
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 85 of Group 10 secretory phospholipase A2
Cysteine 139 of Group 10 secretory phospholipase A2
6g5j B 58 B 90
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 100 and 132 (58 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6g5j
Structure name
secreted phospholipase a2 type x in complex with ligand
Structure deposition date
2018-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
100
Residue number B
132
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 100 of Group 10 secretory phospholipase A2
Cysteine 132 of Group 10 secretory phospholipase A2
4uy1 B 48 B 49
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 90 and 91 (48 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
4uy1
Structure name
novel pyrazole series of group x secretory phospholipase a2 (spla2-x) inhibitors
Structure deposition date
2014-08-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
90
Residue number B
91
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 90 of Group 10 secretory phospholipase A2
Cysteine 91 of Group 10 secretory phospholipase A2
1le7 A 49 A 122
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 91 and 164 (49 and 122 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
1le7
Structure name
carboxylic ester hydrolase, c 2 2 21 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
91
Residue number B
164
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 91 of Group 10 secretory phospholipase A2
Cysteine 164 of Group 10 secretory phospholipase A2
5g3m A 27 A 97
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 69 and 139 (27 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5g3m
Structure name
discovery of a novel secreted phospholipase a2 (spla2) inhibitor
Structure deposition date
2016-04-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
69
Residue number B
139
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 69 of Group 10 secretory phospholipase A2
Cysteine 139 of Group 10 secretory phospholipase A2
1le6 A 49 A 58
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 91 and 100 (49 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
91
Residue number B
100
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 91 of Group 10 secretory phospholipase A2
Cysteine 100 of Group 10 secretory phospholipase A2
5owc A 76 A 90
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 118 and 132 (76 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5owc
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
118
Residue number B
132
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 118 of Group 10 secretory phospholipase A2
Cysteine 132 of Group 10 secretory phospholipase A2
1le6 B 11 B 76
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 53 and 118 (11 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
53
Residue number B
118
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 53 of Group 10 secretory phospholipase A2
Cysteine 118 of Group 10 secretory phospholipase A2
1le6 C 88 C 90
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 130 and 132 (88 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1le6
Structure name
carboxylic ester hydrolase, p 1 21 1 space group
Structure deposition date
2002-04-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
130
Residue number B
132
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 130 of Group 10 secretory phospholipase A2
Cysteine 132 of Group 10 secretory phospholipase A2
5g3m B 25 B 27
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 67 and 69 (25 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5g3m
Structure name
discovery of a novel secreted phospholipase a2 (spla2) inhibitor
Structure deposition date
2016-04-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
67
Residue number B
69
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 67 of Group 10 secretory phospholipase A2
Cysteine 69 of Group 10 secretory phospholipase A2
5ow8 B 48 B 90
A redox-regulated disulphide may form within Group 10 secretory phospholipase A2 between cysteines 90 and 132 (48 and 90 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5ow8
Structure name
indole-2 carboxamides as selective secreted phospholipase a2 type x (spla2-x) inhibitors
Structure deposition date
2017-08-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15496
Residue number A
90
Residue number B
132
Peptide name
Group 10 secretory phospholipase A2
Ligandability
Cysteine 90 of Group 10 secretory phospholipase A2
Cysteine 132 of Group 10 secretory phospholipase A2
If this tool was useful for finding a disulphide, please cite: