ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Circadian locomoter output cycles protein kaput

Intramolecular
Cysteine 324 and cysteine 337
Cysteine 194 and cysteine 195
A redox-regulated disulphide may form within Circadian locomoter output cycles protein kaput between cysteines 324 and 337.

Details

Redox score ?
78
PDB code
4f3l
Structure name
crystal structure of the heterodimeric clock:bmal1 transcriptional activator complex
Structure deposition date
2012-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
58
Peptide accession
O08785
Residue number A
324
Residue number B
337
Peptide name
Circadian locomoter output cycles protein kaput

Ligandability

Cysteine 324 of Circadian locomoter output cycles protein kaput

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of Circadian locomoter output cycles protein kaput

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Circadian locomoter output cycles protein kaput between cysteines 194 and 195. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6qpj
Structure name
human clock pas-a domain
Structure deposition date
2019-02-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
44
Peptide accession
O15516
Residue number A
194
Residue number B
195
Peptide name
Circadian locomoter output cycles protein kaput

Ligandability

Cysteine 194 of Circadian locomoter output cycles protein kaput

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Circadian locomoter output cycles protein kaput

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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