3-phosphoinositide-dependent protein kinase 1

Intramolecular

A redox-regulated disulphide may form within 3-phosphoinositide-dependent protein kinase 1 between cysteines 260 and 327. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5hng

Structure name

discovery of novel 7-azaindoles as pdk1 inhibitors

Structure deposition date

2016-01-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

O15530

Residue number A

260

Residue number B

327

Peptide name

3-phosphoinositide-dependent protein kinase 1

Ligandability

Cysteine 260 of 3-phosphoinositide-dependent protein kinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.