ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Retinoschisin

Intramolecular
Cysteine 63 and cysteine 219
Cysteine 110 and cysteine 142
A redox-regulated disulphide may form within Retinoschisin between cysteines 63 and 219.

Details

Redox score ?
94
PDB code
5n6w
Structure name
retinoschisin r141h mutant
Structure deposition date
2017-02-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O15537
Residue number A
63
Residue number B
219
Peptide name
Retinoschisin

Ligandability

Cysteine 63 of Retinoschisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Retinoschisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoschisin between cysteines 110 and 142.

Details

Redox score ?
69
PDB code
5n6w
Structure name
retinoschisin r141h mutant
Structure deposition date
2017-02-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
10
Peptide accession
O15537
Residue number A
110
Residue number B
142
Peptide name
Retinoschisin

Ligandability

Cysteine 110 of Retinoschisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of Retinoschisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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