ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Intermediate conductance calcium-activated potassium channel protein 4

Intramolecular
Cysteine 276 and cysteine 277
Cysteine 267 and cysteine 269
A redox-regulated disulphide may form within Intermediate conductance calcium-activated potassium channel protein 4 between cysteines 276 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6cnn
Structure name
cryo-em structure of the human sk4/calmodulin channel complex in the ca2+ bound state i
Structure deposition date
2018-03-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
44
Peptide accession
O15554
Residue number A
276
Residue number B
277
Peptide name
Intermediate conductance calcium-activated potassium channel protein 4

Ligandability

Cysteine 276 of Intermediate conductance calcium-activated potassium channel protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Intermediate conductance calcium-activated potassium channel protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Intermediate conductance calcium-activated potassium channel protein 4 between cysteines 267 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6cnn
Structure name
cryo-em structure of the human sk4/calmodulin channel complex in the ca2+ bound state i
Structure deposition date
2018-03-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
74
Peptide accession
O15554
Residue number A
267
Residue number B
269
Peptide name
Intermediate conductance calcium-activated potassium channel protein 4

Ligandability

Cysteine 267 of Intermediate conductance calcium-activated potassium channel protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Intermediate conductance calcium-activated potassium channel protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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