ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leucocyte antigen

Intramolecular
Cysteine 122 and cysteine 185
Cysteine 224 and cysteine 280
A redox-regulated disulphide may form within Leucocyte antigen between cysteines 122 and 185 (101 and 164 respectively in this structure).

Details

Redox score ?
83
PDB code
7emb
Structure name
mooring stone-like arg114 pulls diverse bulged peptides: first insight into african swine fever virus-derived t cell epitopes presented by swine major histocompatibility complex class i
Structure deposition date
2021-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19075
Residue number A
122
Residue number B
185
Peptide name
Leucocyte antigen

Ligandability

Cysteine 122 of Leucocyte antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Leucocyte antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leucocyte antigen between cysteines 224 and 280 (203 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
7em9
Structure name
mooring stone-like arg114 pulls diverse bulged peptides: first insight into african swine fever virus-derived t cell epitopes presented by swine major histocompatibility complex class i
Structure deposition date
2021-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19075
Residue number A
224
Residue number B
280
Peptide name
Leucocyte antigen

Ligandability

Cysteine 224 of Leucocyte antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Leucocyte antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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