ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II HLA-DQ-beta-1

Intramolecular
Cysteine 117 and cysteine 173
Cysteine 15 and cysteine 79
A redox-regulated disulphide may form within MHC class II HLA-DQ-beta-1 between cysteines 117 and 173.

Details

Redox score ?
80
PDB code
5ujt
Structure name
crystal structure of human hla-dq8 in complex with insulin mimotope binding in register 3
Structure deposition date
2017-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19707
Residue number A
117
Residue number B
173
Peptide name
MHC class II HLA-DQ-beta-1

Ligandability

Cysteine 117 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II HLA-DQ-beta-1 between cysteines 15 and 79 (57 and 121 respectively in this structure).

Details

Redox score ?
79
PDB code
6xco
Structure name
immune receptor complex
Structure deposition date
2020-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O19707
Residue number A
15
Residue number B
79
Peptide name
MHC class II HLA-DQ-beta-1

Ligandability

Cysteine 15 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of MHC class II HLA-DQ-beta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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